Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

2006-08-08

2006-08-08

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C546S119000, C546S143000, C546S153000, C546S159000, C546S255000, C546S275400, C546S275700, C544S124000, C544S360000, C514S253010, C514S303000, C514S314000, C514S333000, C514S338000, C514S340000

Reexamination Certificate

active

07087603

ABSTRACT:
This invention describes novel pyrazole compounds of formula IV:wherein Z1or Z2is nitrogen, Q is —S—, —O—, —N(R4)—, —C(R6′)2—, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3-cyclobutanediyl, and R1is T-Ring D, wherein Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rxand Ryare independently selected from T—R3or L—Z—R3, or Rxand Ryare taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5–7 membered ring having 0–3 heteroatoms; and R2and R2′are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

REFERENCES:
patent: 3755332 (1973-08-01), Wasley et al.

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