One-pot process for the preparation of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07081539

ABSTRACT:
A process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide without isolation of intermediates in solid form, by using 4-hydroxycoumarin as a starting compound, and water and 1,2-dichloroethane as solvents; and an industrially useful process for the preparation of 1,2-benzisoxazole-3-acetic acid, by reacting 4-hydroxycoumarin and hydroxylamine in water.

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Hitoshi Uno et al., “Studies on 3-Substituted 1,2-Benzisoxazole Derivatives. 6. Syntheses of 3-(Sulfamoylmethyl)-1,2-benzisoxazole Derivatives and Their Anticonvulsant Activities”, J. Med. Chem., 22, pp. 180-183, 1979.
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P. Thourel et al., Syntheses D'Acide Benzisoxazole-1,2 Acetique-3 (14C-α) ET(14C-β), J. Labell. Compd. Radiopharm., 25, pp. 1235-1244, 1988.
Masanao Shimizu et al., “Research and Development of Zonisamide, a New Type of Antiepileptic Drug”, Yakugaku-Zasshi, vol. 116, pp. 533-547, 1996.
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Giovanni Casini et al., “On 1,2-Benzisoxazole-3-acetic Acid (1)”, J. Heterocycl. Chem., 2, 385-386, 1965.

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