Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-08
2006-08-08
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S297000
Reexamination Certificate
active
07087622
ABSTRACT:
In accordance with the present invention, compounds that inhibit Type III protein section have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein section and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.
REFERENCES:
patent: WO 98/13043 (1998-04-01), None
patent: WO 99/26926 (1999-06-01), None
patent: WO 01/40189 (2001-06-01), None
patent: WO 03/103668 (2003-12-01), None
Dragovich, P.S. et al., “Structure-Based Design, Synthesis and Biological Evaluatin of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure-Activity Studies of Orally Bioavailable, 2-Pyridone-Cntaining Peptidomimetics”, J. Med. Chem vol. 45, 2002, pp. 1607-1623.
PCT International Search Report, dated Oct. 5, 2005, for PCT Int'l. Appln. No. PCT/US2005/015811.
Davis Zinna N.
Dodd Thomas
Janssen Pharmaceutica N.V.
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