Method of measuring platelet activation

Details Method of measuring platelet activation Method of measuring platelet activation

2006-03-14

2006-03-14

Witz, Jean C. (Department: 1651)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C435S372000, C436S018000, C436S176000

Reexamination Certificate

active

07011938

ABSTRACT:
Platelet activation is measured by determining Mean Platelet Component (MPC) of suspended blood platelets, using a specific anticoagulant composition. The composition comprises at least one component for effecting platelet sphering (for example EDTA), and at least one platelet antagonist (for example at least one of, and preferably all three of theophylline, adenosine and dipyridamole).

REFERENCES:
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patent: 08-220094 (1996-08-01), None
Franchi et al. “The beta-thromboglobulin test” Thromb. and Haemostasis (1980) 44(2): 107.
Chapman et al. “The use of the anticoagulant C.T.A.D. for the assessement of ex vivo platelet activation on the ADVIA 120 haematology system” Blood (Nov. 16, 2000) vol. 96, not 11, part 2, p. 52b.
Nagata et al. “Anticoagulants preventing pseudo-thrombocytopenia” Rinsho Byori (1992) 40(1): 87-92 (English abstract only).
Kuhne et al. “Flow Cytometric Evaluation of Platelet Activation in Blood Collected Into EDTA vs. Diatube-H, a Socium Citrate Solution Supplememted with Theophylline, Adenosine, and Dipyradamole,” Am. J. Hematol. (1995) 50: 40-45.

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