Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1995-06-01
2000-03-07
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241411, 4241431, 4241441, 514 2, 530300, 530350, 5303871, 53038822, 5303891, 530395, A61K 3800, A61K 39395
Patent
active
06033665&
ABSTRACT:
The invention is directed to compositions and methods for modulating the adhesion of leukocytes to brain endothelial cells. More specifically, the present invention relates to the use of reagents to inhibit the binding of VLA-4 leukocyte cell surface receptors to brain endothelial adhesion molecules. Also provided are compositions and methods for treating brain inflammation. A method of inducing brain inflammation as well as an assay for testing anti-inflammatory agents is also provided.
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Elan Pharmaceuticals Inc.
Hutzell Paula K.
Johnson Nancy A.
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