Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-09-19
2006-09-19
Sullivan, Daniel M. (Department: 1636)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07109173
ABSTRACT:
The invention discloses the discovery of naturally occurring peptides that contain fatty acyl and prenyl moieties which permit the transfer of nucleotides, oligonucleotides, and polynucleotides into the cytoplasm and nucleus of cells. Their intrinsic properties cause them to tightly bind to nucleotides. This indicates that they might serve as nucleotide transporters. Experiments demonstrated that they permitted the transfer of nucleotides and polynucleotides into the cytoplasm and nucleus of cells. The peptides, due to their ability to transport ribonucleic acids into cells, can be employed in gene silencing by RNAi (ribonucleic acid interference) and antisense therapy. Among the ailments thought to benefit are: atherosclerosis by regulating cholesterol metabolism, cancer and similar diseases by delivering nucleic acids in chemotherapy. The peptides, due to their ability to transport ribonucleic acids into cells, can be employed in gene silencing.
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Friedman Lori M.
Guidry Guy
Sullivan Daniel M.
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