Pyrrolo[1,2-b]pyridazine compounds and their uses

Details Pyrrolo[1,2-b]pyridazine compounds and their uses Pyrrolo[1,2-b]pyridazine compounds and their uses

2006-05-09

2006-05-09

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S235000

Reexamination Certificate

active

07041671

ABSTRACT:
Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I):including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

REFERENCES:
patent: 1085021 (1999-05-01), None
patent: 9808847 (1998-03-01), None
patent: 02072101 (2002-09-01), None
patent: 02072202 (2002-09-01), None
Chorvat et al. (J. Med. Chem. (2000), 42: 833-848).
(He et al. J. Med. Chem. (2000), 43:449-456).

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