Use of peptide

Details Use of peptide Use of peptide

2006-05-16

2006-05-16

Murphy, Joseph (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C530S315000, C530S300000, C435S007100, C435S375000, C424S198100, C536S023510, C536S023100

Reexamination Certificate

active

07045497

ABSTRACT:
The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserving or treating various diseases related to oxytocin secretion such as uterine inertia, atonic hemorrhage, placental expulsion, subinvolution and the like.

REFERENCES:
patent: WO 98/58962 (1998-06-01), None
patent: WO 97/24436 (1997-07-01), None
Minoru Maruyama, et al., Central Administration of Prolactin-Releasing Peptide Stimulates Oxytocin Release in Rats,Neuroscience Letters, 1999, vol. 276, pp193-196.
Minoru Maruyama, et al., Immunocytochemical Localization of Prolactin-Releasing Peptide in the Rat Brain,Endocrinology, 1999, vol. 140, pp2326-2333.
Shuji Hinuma, et al., A Prolactin-Releasing Peptide in the Brain,Nature, May 21, 1998, vol. 393, pp272-276.
C.J.C. Boersma, et al., Immunocytochemical Localization of Neuropeptide FF (FMRFAmide-Like Peptide) in the Hypothalamo-Neurohypophyseal System of Wistar and Brattleboro Rats by Light and Electron Microscopy,The Journal of Comparative Neurology. 1993, vol. 336, pp555-570.

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