Process for the production of 9-(Z)-retinoic acid

Details Process for the production of 9-(Z)-retinoic acid Process for the production of 9-(Z)-retinoic acid

2006-03-21

2006-03-21

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

07015353

ABSTRACT:
A process for the production of 9-(Z)-retinoic acid is described which comprises reacting an alkali metal salt of 3-methyl-4-oxocrotonic acid with a C15-triphenyl-phosphonium salt. 9-(Z)-retinoic acid is used in the treatment of dermatological diseases.

REFERENCES:
patent: 5504230 (1996-04-01), John et al.
patent: 1068710 (1959-11-01), None
patent: 0659739 (1994-12-01), None
patent: WO 99/09969 (1999-03-01), None
Rüegg, et al., Helv. 44 985 (1961).

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