Method for producing therapeutically suitable glutaminase

Details Method for producing therapeutically suitable glutaminase Method for producing therapeutically suitable glutaminase

2006-05-30

2006-05-30

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Bacteria or actinomycetales

C424S094600, C424S260100, C424S201100, C536S023700, C435S069100

Reexamination Certificate

active

07052689

ABSTRACT:
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anticancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.

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