Pyrimidine derivatives as IL-8 receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S266400, C514S269000, C514S235800, C544S320000, C544S319000, C544S270000, C544S122000, C544S123000, C544S114000, C544S115000

Reexamination Certificate

active

07037916

ABSTRACT:
Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula IIn these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is:

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