Vitamin B12 and pemetrexed disodium combination therapies

Details Vitamin B12 and pemetrexed disodium combination therapies Vitamin B12 and pemetrexed disodium combination therapies

Filed on

2006-05-30

Date issued

2006-05-30

Examiner

Low, Christopher S. F. (Department: 1614)

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Carbohydrate doai

Other Related Categories

C514S249000, C514S077000, C514S251000, C514S265100

Type

Reexamination Certificate

Status

active

Patent number

07053065

Description

ABSTRACT:
A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.

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Dierkes et al., Supplementation with Vitamin B12 Decreases Homocystein and Methylmalonic Acid but Also Serum Folate in Patients with End-Stage Renal Disease. Metabolism. May 1999. vol. 48, No. 5, pp. 631-635. See: abstract.
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Calvert, H., “Future directions in the development of pemetrexed,” Seminars In Oncology, 29/2 Suppl. 5 (54-61) (2002) ; XP009005744.
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Hanauske, et al., “Premetrexed Disodium: A novel antitolate clinically active againstmultiple solid tumors,” Oncologist, Alphamed Press, US, vol. 4, No. 6, (2001) pp. 363-373; XP008005752.
Runn, et al., “Vitamin B12 and tolate reduce toxicity of alimta (pemetrexed disodium, LY233514, MTA), A novel antifolate/antimetabolite,” Program/ Proceedings—American Society of Clinical Oncology, The Society, US, vol. 76A, No. 20 (2001) p. 300; XP008005885.
Westerhef, et al., “Carrier- and receptor-mediated transport of folate antagonists targeting folate dependent exzymes: correlates of molecular-structure and biological activity,” Mol. Pharmacol., 48(3), 459-471 (1995) ; XP008005762.
Warralla, et al., “ Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514,” Anticancer Research, 18(5A), 3235-3239 (1998) ; XP008005757.
Hanauske, et al., “Premetrexed Disodium: A novel antitolate clinically active againstmultiple solid tumors,” Oncologist Alphamed Press, US, vol. 4, No. 4, (2001) pp. 363-373; XP008005752.
Bunn, et al., “Vitamin B12 and folate reduce toxicity of alimta (pemetrexed disodium, LY231514, MTA), A novel antifolate/antimetabolite,” Program/ Proceedings—American Society of Clinical Oncology, The Society, US, vol. 76A, No. 20 (2001) p. 3000; XP008005885.

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