VGF fusion polypeptides

Details VGF fusion polypeptides VGF fusion polypeptides

2006-03-07

2006-03-07

Brumback, Brenda (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C530S399000

Reexamination Certificate

active

07008924

ABSTRACT:
The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.

REFERENCES:
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Rudinger, In, “Peptide Hormones” (Ed. J.A. Parsons) University Park Press, Baltimore, pp. 1-7, 1975.
Canu et al., “Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF.”Genomics15:443-6 (1997).
Schwartz et al., “Hypothalamic response to starvation: implications for the study of wasting disorders.”Am J Physiol269:949-57 (1995).
Hahm et al., “Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.”Neuron23:537-48 (1999).
Liu et al., “Peptide V: a VGF-derived neuropeptide purified from bovine posterior pituitary.”Endocrinology135:2742-8 (1994).
Trani et al., “Tissue-specific processing of the neuroendocrine protein VGF.”J Neurochem65:2441-9 (1995).
Miyatake et al., “The signal transduction pathway for VGF expression due to NGF is different from that due to bFGF in PC12h cell.”Biochem Mol Biol Int30:231-6 (1993).
Altshuler and Hirschhorn. “Upsetting the Balance: VGF and the Regulation of Body Weight.”Neuron. 23:415-417 (1999).

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