Urinary tract tissue graft compositions and methods for...

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell

Reexamination Certificate

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Reexamination Certificate

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07078033

ABSTRACT:
A method for repairing damaged or diseased urinary tract tissue includes providing a urinary tract tissue graft composition that includes a distal ileal segment of small intestinal submucosa. The distal ileal segment of small intestinal submucosa may be utilized as an unseeded tissue graft composition, or the distal ileal segment of small intestinal submucosa may be positioned in a tissue culture frame, and smooth muscle and urothelial cells isolated from a tissue specimen of a subject and cultured are then seeded upon the distal ileal segment of small intestinal submucosa, thereby forming a urinary tract tissue graft.

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patent: 2003/0216811 (2003-11-01), Badytak
Zhang et al.; “‘Co-Culture’ of Bladder Smooth Muscle And Urothelila Cells On Small Intestinal Submococa (sis): Evaluation Of The Best Culture Method For In Vitro Tissue Engineering Techniques”; Pediatrics Journal Supp: Sep., 1998:807-808.
Lu et al.; “Muscle-Derived Stem Cells Seeded Into Acellular Scaffolds Develop Calcium-Dependent Contractile Activity That Is Modulated By Nicotinic Receptors”; Urology 61:1285-1291, 2003.
Zhang, Y. et al.; “Coculture of Bladder Urothelila and Smooth Muscle Cells on Small Intestinal Submucosa: Potential Applications for Tissue Engineering Technology”; Journal of Urology 164:928-935 (2000).

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