Process for production cilostazol

Details Process for production cilostazol Process for production cilostazol

2006-04-11

2006-04-11

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S157000

Reexamination Certificate

active

07026486

ABSTRACT:
The present invention provides a process for producing cilostazol [I] in a high yield and a high purity, by reacting a carbostyril derivative [II] with a tetrazole derivative [III] in the presence of an inorganic basic compound in a solvent of water, wherein water is used in an amount of 3 to 7-fold weight to that of the carbostyril derivative [II] and the inorganic basic compound is used in an amount of 1 to 6 mol per mol of the carbostyril derivative [II]. The process of the present invention is the improved and environment-friendly process for producing cilostazol being useful for pharmaceuticals

REFERENCES:
patent: 4277479 (1981-07-01), Nishi et al.
patent: 6515128 (2003-02-01), Mendelovici et al.
patent: 6630590 (2003-10-01), Aki et al.
patent: 550434 (1985-12-01), None
patent: 56-45414 (1981-04-01), None
patent: 56-46810 (1981-04-01), None
patent: 58-59980 (1983-04-01), None
patent: 58-077880 (1983-05-01), None
patent: 59-157084 (1984-09-01), None
patent: 1-265051 (1989-10-01), None
patent: 2000-229953 (2000-08-01), None
patent: 2001-213877 (2001-08-01), None
patent: WO 02/14283 (2002-02-01), None
Nishi, CA 99:98806, Chem & Pharm Bull, 1983, vol. 31(4), pp 1151-1157.
Nishi, CA 103:141893, Chem & Pharm Bull, vol. 33(3), pp 1140-1147, 1985.
Nishi; “Research and Development for Platelet Function Inhibitor”; The 29thSymposium on the Chemistry of Natural Products, pp. 41-43, (1994).
Nishi et al.; “Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. II. 6-[3-(1-Cyclohexyl-5-Tetrazolyl)Propoxy]-1,2-Dihydro-2-Oxoquinoline and Related Compounds”; Chem. Pharm. Bull., vol. 31., No. 4, pp. 1151-1157, (1983).
Nishi et al.; Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. IV.1)Synthesis and Biological Activity of the Metabolites of 6-[4-(1-Cyclohexyl-1H -5-Tetrazolyl)Butoxy]-2-Oxo-1,2,3,4-Tetrahydroquinoline (OPC-13013); Chem. Pharm. Bull. vol. 33, No. 3, pp. 1140-1147, (1985).

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