Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-11
2006-04-11
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S405000, C546S268400, C514S338000, C514S339000
Reexamination Certificate
active
07026324
ABSTRACT:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein R2 is R3 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C1–4 alkyl, 4) C3–7 cycloalkyl, 5) CF3, 6) OCF3, 7) C1–4 alkoxy, and 8) cyano; and R12 is a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 1 heteroatom is N, and at most 1 of the heteroatoms is S, said ring being unsubstituted or substituted, at any one ring atom, with CH3.
REFERENCES:
patent: 6521625 (2003-02-01), Cowden et al.
patent: 6867217 (2005-03-01), South et al.
patent: 2002/0037875 (2002-03-01), Semple et al.
patent: WO 99/11267 (1999-03-01), None
Nantermet Philippe G.
Selnick Harold G.
Williams Peter D.
Young Mary Beth
Camara Valerie J.
Merck & Co. , Inc.
Parr Richard S.
Tucker Zachary C.
Wilson James O.
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