Benzoimidazole derivatives useful as antiproliferative agents

Details Benzoimidazole derivatives useful as antiproliferative agents Benzoimidazole derivatives useful as antiproliferative agents

2006-07-04

2006-07-04

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S313000, C514S314000

Reexamination Certificate

active

07071337

ABSTRACT:
The invention relates to compounds of the formula 1and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, and R4are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

REFERENCES:
patent: 0140217 (2001-06-01), None
patent: WO 01/40214 (2001-06-01), None
Palmer BD et al. Journal of Medicinal Chemistry, vol. 42, 1999, pp. 2373-2382, XP002157335.
Palmer BD et al. Journal of Medicinal Chemistry, vol. 41, 1998, pp. 5457-5465, XP002157336.

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