Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-03-07
2006-03-07
Caputa, Anthony C. (Department: 1642)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S069100, C435S070100, C435S070300, C435S071100, C435S320100, C435S325000
Reexamination Certificate
active
07009043
ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
REFERENCES:
Bowie et al (Science, 247: 1306-1310, 1990).
Burgess et al (J. Cell Biology, 111: 2129-2138, 1990).
Lazar et al (Molecular and Cellular Biology, 8: 1247-1252, 1988).
Brown et al., “Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis,”J Cell Biol125:1303-12 [1994].
Duesbery et al., “CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II,”Proc Natl Acad Sci U S A94:9165-7 [1997].
Hyman and Mitchison, “Two different microtubule-based motor activities with opposite polarities in kinetochores,”Nature351:206-11 [1991].
Kodama et al., “The initial phosphate burst in ATP hydrolysis by myosin and subfragment-1 as studied by a modified malachite green method for determination of inorganic phosphate,”J Biochem(Tokyo) 99:1465-72 [1986].
Liao et al., “Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein,”Science265:394-8 [1994].
Lombillo et al., “Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro,”J. Cell Biol128:107-15 [1995].
Mitchison and Kirschner, “Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation,”J Cell Biol101:766-77 [1985].
Rattner et al., “The centromere kinesin-like protein, CENP-E. An autoantigen in systemic sclerosis,”Arthritis Rheum39:1355-61 [1996].
Sakowicz et al., “A marine natural product inhibitor of kinesin motors,”Science280:292-5 [1998].
Stewart et al., “Direction of microtubule movement in an intrinsic property of the motor domains of kinesin heavy chain and Drosphila ncd protein,”Proc Natl Acad Sci U S A90:5209-13 [1993].
Thrower et al., “Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor,”EMBO J14:918-26 [1995].
Wood et al., “CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment,”Cell91:357-66 [1997].
Yen et al., “CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase,”EMBO J10:1245-54 [1991].
Yen et al., “CENP-E is a putative kinetochore motor that accumulates just before mitosis,”Nature359:536-9 [1992].
Gordon et al., “Overexpression of the kinetochore localization domain of CENP-E causes two distinct dominant negative phenotypes,”Mol Biol Cell7 Supplement:565a [1996].
Wood et al., “Characterization of a Xenopus homologue of centromere-associated protein-E (CENP-E),”Mol Biol Cell6 Supplement:361a [1995].
Vafa, O. et al. Mol. Biol. of the Cell, 8 (suppl): 125A, 1997, Nov.
Cleveland Don W.
Goldstein Lawrence S. B.
Sakowicz Roman
Wood Kenneth W.
Caputa Anthony C.
Holleran Anne L.
Medlen & Carroll LLP
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