Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-04-11
2006-04-11
Housel, James C. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S005000, C435S007100, C435S007210
Reexamination Certificate
active
07026130
ABSTRACT:
A 24kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24kd protein, are disclosed. Processes for production and purification of the 24kd protein, and functionally equivalent variants or fragments thereof, are also disclosed, as are methods for using the protein to screen for chemical compounds that bind HCV.
REFERENCES:
patent: 0 318 216 (1988-11-01), None
patent: 0 388 232 (1990-03-01), None
patent: WO 93/04205 (1993-03-01), None
patent: WO 96/04376 (1996-02-01), None
patent: WO 96/05513 (1996-02-01), None
Germi et al., Journal of Medical Virology, vol. 68, pp. 206-215 (2002).
Chien et al., “Diagnosis of Hepatitis C Virus (HCV) Infection Using an Immunodominant Chimeric Polyprotein to Capture Circulating Antibodies: Reevaluation of the Role of HCV in Liver Disease”, Proc. Natl. Acad. Sci. USA., (1992) 89:10011-10015.
Choo et al., “Genetic Organization and Delivery of the Hepatitis C Virus”, Proc. Natl. Acad. Sci. USA., (1991) 88:2451-2455.
Gething et al., “Contraction of Influenza Haemagglutinin Genes that Code for Intracellular and Secreted Forms of the Protein”, Nature (1982) 300:598-603.
Laemmli, “Cleavage of Structural Proteins During the Assembly of the Had of Bacteriophage T4”, Nature (1970) 227:680-685.
Morre et al., “Plasma and Internal Membranes from Cultured Mammalian Cells”, Methods in Enzymology (1994) 228:448-450.
Rosa et al., “A Quantitative Test to Estimate Neutralizing Antibodies to the Hepatitis C Virus: Cytofluorimetric Assessment of Envelope Glycoprotein 2 Binding to Target Cells”, Proc. Natl. Acad. Sci. USA., (1996) 93:1756-1763.
Spaete et al., “Characterization of the Hepatitis C Virus E2/NS1 Gene Product Expressed in Mammalian Cells”, Virology (1992) 188:819-830.
Minutello et al., Journal of Hepatology, 17 (Suppl. 1):55-56.
Rice, C.M., Hepatology 29(3):990-992.
Rowlands et al., pp. 795-808, in Henry, J.B. ed., Clinical Diagnosis & Management by Laboratory Methods, 18thed., W.B. Saunders Compnay, Philadelphia.
Shimonaka et al.., Journal of Biological Chemistry, 269(19):14284-14289.
Bowie et al.., Science, 247:1306-1310 (1990).
Burgess et al., Journal of Cell Biology, 111:2129-2138 (1990).
Lazar et al.., Molecular and Cellular Biology, 8:1247-1252 (1988).
Levy et al., Structure and Menbrane Topology of TAPA-1, The Journal of Biological Chemistry 266(22):14597-14602 (1991)...
Pileri et al., Binding of Hepatitis C Virus to CD81, Science 282:938-941 (1998).
Levy et al., “CD81 (TAPA-1): A Molecule Involved in Signal Transduction and Cell Adhesion in the Immune System,” Annu. Rev. Immunol., 16:89-109 (1998).
Chiron Corporation
Harbin Alisa A.
Housel James C.
Lucas Zachariah
Moran Michael J.
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