Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-07-18
2006-07-18
Harris, Alana M. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S300000, C530S350000, C530S381000, C530S387100, C424S130100, C514S002600
Reexamination Certificate
active
07078490
ABSTRACT:
A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding a monobody, and a variegated nucleic acid library encoding a monobody, are provided by the invention. Also provided are methods of preparing an Fn3 polypeptide monobody, and kits to perform such methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, kcat, and an uncatalyzed rate constant, kuncat, such that the ratio of kcat/kuncatis greater than 10.
REFERENCES:
patent: 6348584 (2002-02-01), Hodgson et al.
patent: 6391855 (2002-05-01), Blaschuk et al.
patent: 6462189 (2002-10-01), Koide
patent: 6673901 (2004-01-01), Koide
patent: 6703199 (2004-03-01), Koide
patent: 6818418 (2004-11-01), Lipovsek et al.
patent: 2003/0027319 (2003-02-01), Koide
patent: 2003/0108948 (2003-06-01), Koide
patent: 2003/0134386 (2003-07-01), Koide
patent: 2003/0170753 (2003-09-01), Koide
patent: 2003/0186385 (2003-10-01), Koide
patent: 2004/0259155 (2004-12-01), Chan et al.
patent: 2005/0038229 (2005-02-01), Lipovsek et al.
patent: 8-511417 (1996-03-01), None
patent: WO 94/18221 (1994-08-01), None
patent: WO 94/24278 (1994-10-01), None
patent: WO-94/24278 (1994-10-01), None
patent: WO 95/27045 (1995-10-01), None
patent: WO 98/56915 (1998-12-01), None
patent: WO 00/34784 (2000-06-01), None
patent: WO 01/64942 (2001-09-01), None
patent: WO 02/04523 (2002-01-01), None
patent: WO 03/104418 (2003-12-01), None
patent: WO 04/019878 (2004-03-01), None
patent: WO 05/056764 (2005-06-01), None
Winter, Greg, et al., “Making Antibodies by Phage Display Technology”, Ann. Rev. Immunol., 12, (1994),433-455.
Barbas, Carlos.F. ,et al. ,“Assembly of combinatorial antibody libraries on phage surfaces: The gene III site”,Proc. Natl. Acad. Sci. USA, 88, (Sep. 1991),7978-7982.
Barbas, Carlos.D. ,et al. ,“Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem”,Proc. Natl. Acad. Sci. USA, 89, (May 1992),4457-4461.
Baron, M..,et al. , “Protein modules”,TIBS, vol. 16,(Jan. 1991), 13-17.
Bazan, J..F. ,“Structural design and molecular evolution of a cytokine receptor superfamily”,Proc. Natl. Acad. Sci. USA, vol. 87,(Sep. 1990),6934-6938.
Bianchi Elisabetta., “High Level Expression and Rational Mutagenesis of a Designed Protein, the Minibody”,J. Mol. Bio., 236, (1994),649-659.
Bork, Peer.,et al. ,“Proposed acquisition of an animal protein domain by bacteria”,Proc. Natl. Acad. Sci. USA, 89, (Oct. 1992),8990-8994.
Bork, P..,et al. ,“Review: The Immunoglobulin Fold—Structural Classification, Sequence Patterns and Common Core”,J. Mol. Biol., vol. 242,(1994),309-320.
Burgess, Wilson.H. ,et al. ,“Possible Dissociation of the Heparin-binding and Mitogenic Activities of Heparin-binding (Acidic Fibroblast) Growth Factor-1 from Its Receptor-binding Activities by Site Directed Mutagensis of a Single Lysine Residue”,The Journal of Cell Biology, 111, (Nov. 1992),2129-2138.
Campbell, Iain.C. , et al. , “Building proteins with fibronectin type III modules”,Structure, vol. 2,(May 15, 1994),333-337.
Clarkson, Tim.,et al. ,“In vitro selection from protein and peptide libraries”,Trends in Biotechnology, 12, (May 1994),173-184.
Clore, G..M. , et al. , “Structures of Larger Proteins in Solution: Three-and Four-Demensional Heteronuclear NMR Spectroscopy”,Science, 252, (Jun. 7, 1991), 1390-1399.
Cota, Ernesto.,et al. ,“Two proteins with the same structure respond very differently to mutation: The role of plasticity in protein stability”,J. Mol. Biol., vol. 302,(2000),713-725.
Davies, Julian.,et al. ,“Antibody VH Domains as Small Recognition Units”,Bio/Technol., 13, (1995),475-479.
Desiderio, Angiola.,et al. ,“A semi-synthetic repertoire of intrinsically stable antibody fragments derived from a single-framework scaffold”,J. Mol. Biol., vol. 310,(2001),pp. 603-615.
Doolittle, Russell.F. ,“The multiplicity of domains in proteins”,Annu. Rev. Biochem., vol. 64,(1995),287-314.
Dougall, William.C. ,et al. ,“Antibody-structure-based design of pharmacological agents”,Trends in Biotechnology, 12, (1994),372-379.
Ely, Kathryn,R. ,et al. ,“Common Molecular Scaffold for Two Unrelated RGD Molecules”,Protein Engineering, 8, (1995), 823-827.
Green, Susan.M. ,et al. ,“Contributions of the polar, uncharged amino acids to the stability of Staphylococcal nuclease: Evidence for mutational effects on the free energy of the denatured state”,Biochemistry, vol. 31, No. 25,(1992),5717-5728.
Grumet, M.., et al. ,“Structure of a New Nervous System Glycoprotein, Nr-CAM, and its Relationship to Subgroups of Neural Cell Adhesion Molecules”,the Journal of Cell Biology, 113, (Jun., 1991),1399-1412.
Helms, Larry.R. ,et al. ,“Destabilizing loop swaps in the CDRs of an immunoglobulin VI domain”,Protein Science, vol. 4, (1995),2073-2081.
Holliger, Philipp.,et al. ,““Diabodies”: Small bivalent and bispecific antibody fragments”,Proc. Natl. Acad. Sci. USA, 90, (Jul. 1993),6444-6448.
Holm, L..,et al. ,“FSSP: select structural neighbours of 1fnf”,Science, 273(5275):595-60 http://jura.ebi.ac.uk:8765/holm/qz?filename=/data/research/fssp//1fnf.fssp,(1996),3 pages.
Holm, Liisa.,et al. ,“Mapping the protein universe”,Science, vol. 273,(Aug. 2, 1996),p. 595-602.
Hu, Shi-Zhen.,et al. , “Minibody: A Novel Engineered Anti-Carcinoembryonic Antigen Antibody Fragment (Single-Chain Fv-CH3) Which Exhibits Rapid, High-Level Targeting Xenografts”,Cancer Research, 56, (Jul. 1, 1996),3055-3061.
Janda, Kim.D. ,et al. ,“Chemical Selection for Catalysis in Combinatorial Antibody Libraries”,Science, 275, (Feb. 14, 1997),945-948.
Koide, Shohei.,et al. ,“Directed Evolution of fibronectin type III domain to novel ligand binding proteins”,FASEB Journal, vol. 11, No. 9: pA1155 (1997) (XP002088956), 17th International Congress of Biochemistry and Molecular Biology in conjunction with the Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Francisco, CA, Aug. 24-49, 1997; ISSN: 0892-6638,Abstract only (1 page).
Koide, A..,et al. ,“The fibronectin type III domain as a scaffold for novel binding proteins”,J. Mol. Biol., vol. 284,(1998),pp. 1141-1151.
Lazar, Eliane.,et al. ,“Transforming Growth Factor alpha: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities”,Molecular and Cellular Biology, 8, (Mar., 1988), 1247-1252.
Lee, G..,et al. ,“Strong Inhibition of Fibrinogen Binding to Platelet Receptor alphallbbeta3 by RGD Sequences Installed Into a Presentation Scaffold”,Protein Engineering, 6, (1993),745-754.
Lerner, Richard.A. ,et al. ,“Using the Process of Reactive Immunization to Induce catalytic Antibodies with Complex Mechanisms: Aldolases”,Acta Chemica Scandinavica, 50, (1996),672-677.
Li, Bing.,et al. ,“Minimization of Polypeptide Hormone”,Science, 270, (Dec. 8, 1995), 1657-1660.
Lin, Michael.C. , et al. ,“Structure Function Relationships in Glucagon: properties of highly purified Des-His1-, monoiodo-, and [Des-Asn28-,thr29](homoserine lactone27)-glucagon”,Biochemistry, vol. 14, No. 8, (1975),1559-1563.
Main, Alison.L. ,et al. ,“The Three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions”,Cell, vol. 71,(Nov. 13, 1992),671-678.
Marti-Renom, Marc.A. ,et al. ,“Comparative protein structure modeling of genes and genomes”,Annu. Rev. Biophys. Biomol. Struct., vol. 29,(2000),291-325.
Martin, Mar
Harris Alana M.
Research Corporation Technologies Inc.
Viksnins Harris & Padys PLLP
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