Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Reexamination Certificate
2006-07-04
2006-07-04
McKenzie, Thomas C. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
C514S089000, C514S277000, C514S340000, C514S345000, C514S352000, C514S354000, C514S357000, C546S013000, C546S022000, C546S268400, C546S301000, C546S309000, C546S323000, C546S341000
Reexamination Certificate
active
07071175
ABSTRACT:
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases associated with carboxypeptidase U. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds: to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.
REFERENCES:
patent: 3091569 (1963-05-01), Sheffner
patent: 3766206 (1973-10-01), Hess et al
patent: 4113715 (1978-09-01), Ondetti et al.
patent: 4177277 (1979-12-01), Ondetti et al.
patent: 4537727 (1985-08-01), Barton et al.
patent: 5254579 (1993-10-01), Poli et al.
patent: 5506259 (1996-04-01), Norcini et al.
patent: 3838467 (1990-05-01), None
patent: 0136883 (1985-04-01), None
patent: 0300100 (1989-01-01), None
patent: 0318859 (1989-06-01), None
patent: 0361365 (1990-04-01), None
patent: 0470686 (1992-02-01), None
patent: 0636621 (1995-02-01), None
patent: 0852225 (1998-07-01), None
patent: 1393338 (1965-02-01), None
patent: 2266502 (1975-10-01), None
patent: 2430945 (1980-02-01), None
patent: 1593469 (1981-07-01), None
patent: 01254654 (1989-10-01), None
patent: 2055834 (1996-03-01), None
patent: WO 93/08181 (1993-04-01), None
Chemical Abstracts Documents No. 112:197646 , abstract of JP 01254654 A2.
Boffa, M.B. et al, Curr Drug Targets Cardiovasc Haematol Disord. Dec. 2001;1(2):59-74., Medline abstract PMID: 12769657.
U.S. Appl. No. 09/600,660, filed Jul. 20, 2000, Linschoten et al.
U.S. Appl. No. 09/600,659, filed Jul. 20, 2000, Abrahamsson et al.
Chem. Abstr. 116: 83328, Mimura, et al., J. Med. Chem. 35, 602-608 (1992).
Derwent Abstr. 89-211491/29, JP 01149763 to Dainippon Pharm. KK (1989).
Hirsh, et al., CHEST 2001; 119:1S-2S.
Geerts, et al., CHEST 2001; 119:132S-175S.
Albers, et al., CHEST 2001; 119:194S-206S.
Cairns, et al., CHEST 2001; 119:228S-252S.
Albers, et al., CHEST 2001; 119:300S-320S.
Cohen, Seminars in Thrombosis and Hemostasis 28, suppl. 3, 13-17 (2002).
Barrow et al., J. Med. Chem. 46, 5294-5297 (2003).
Muto et al., Eur. J. Pharmacol. 461, 181-189 (2003).
Suzuki et al., J. Pharmacol. Exper. Ther. 309, 607-615 (2004).
Hashimoto et al., Thromb. Haemost. 87, 110-113 (2002).
Wu et al., Thromb. Haemost. 90, 414-421 (2003).
Nagashima et al., Thromb. Res. 98, 333-342 (2000).
Redlitz et al. Circulation 93, 1328-1330 (1996).
2HU et al, Isolation and characterization of americnin, a specific inhibitor of thrombin, from the salivary glands of the lone star tick Amblyomma americanum (L.), Exp. Parasitol. 87, 30-38 (1997) (abstract only).
Linschoten Marcel
Polla Magnus
Astrazeneca AB
McKenzie Thomas C.
White & Case LLP
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