Amine salts of an integrin receptor antagonist

Details Amine salts of an integrin receptor antagonist Amine salts of an integrin receptor antagonist

2006-07-11

2006-07-11

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S300000

Reexamination Certificate

active

07074930

ABSTRACT:
Amine salts of 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3-(6-methoxy-pyridin-3-yl)propionic acid are potent antagonists of the integrin αvβ3 receptor and are useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salts as well as pharmaceutical compositions containing the salts and methods of using the salts.

REFERENCES:
patent: 3844791 (1974-10-01), Bloom et al.
patent: 6017926 (2000-01-01), Askew et al.
patent: 6426353 (2002-07-01), Arison et al.

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