Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-14
2006-03-14
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S471000, C549S491000, C549S497000, C549S502000
Reexamination Certificate
active
07012094
ABSTRACT:
A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I:wherein Y is selected from O, S and NR1; wherein R1is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2and R3are independently aryl or heteroaryl; and wherein R2and R3are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.
REFERENCES:
patent: 3507648 (1970-04-01), Ford et al.
patent: 3661899 (1972-05-01), Ford et al.
patent: 3743656 (1973-07-01), Brown et al.
patent: 4240820 (1980-12-01), Dickore et al.
patent: 4990647 (1991-02-01), Himmler et al.
patent: 5196532 (1993-03-01), Wuest et al.
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 317845 (1988-11-01), None
patent: 48091058 (1973-11-01), None
patent: 48091061 (1973-11-01), None
patent: 5-012261 (1975-09-01), None
patent: 4-279672 (1992-10-01), None
patent: 94/15932 (1994-07-01), None
patent: 95/00501 (1995-01-01), None
Elderfield-Heterocyclic (pds., vol. 1, John Wiley, N.Y., p. 177-179 and 184-189 (1950).
Dunlop & Peters—The Furans, Roinheld Publishers, p. 170-174 (1953).
Hornfeldt, Svensk Kemisk Tidskrift, vol. 80(10), p. 343-356, (1968).
Yang et al,J. Chem. Soc., 656, (1992).
Kuo et al,Chem. Pharm. Bull., 29, 635-45 (1981).
Lai et al,Tet. Lett., 29, 3483-8/6 (1988).
Ind. J. Chem., 29B, 954-60 (1990).
Synthesis, l, 68-70 (1988).
J. Org. Chem., 47, 183-91 (1982).
J. Heterocycl. Chem., 16(6), 1293-4 (1979).
Indian J. Chem., 12, 1144-6 (1974).
Bull. Soc. Chim. Fr., 10, 3572-8 (1970).
J. Org. Chem., 32, 173-7 (1967).
Chem. Res., 64, 353-88 (1964).
Ind. J. Chem., 12, 336-43 (1974).
Bertenshaw Stephen R.
Talley John J.
Ashbrook Charles
Dentz Bernard
Fitzsimmons Patricia K.
G.D. Searle LLC
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