Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S368000, C514S300000, C514S600000, C514S254020, C548S154000, C548S151000, C546S121000, C544S318000, C544S133000

Reexamination Certificate

active

07022701

ABSTRACT:
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

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Biniecki et al., “Synthesis of 1-(p-aminobenzoyl)-and 1-(2-quinolinoyl)-2-methyl-5-methoxy-3-indoleacetic acids and some amides thereof”, Acta Poloniae Pharmaceutica (1982), 39(1-3), 9-14.
Y. Tsai et al, N1-(Benzenesulfonyl)tryptamines as Novel 5-HT6Antagonists, Bioorganic & Medicinal Chemistry Letters 10 (2000) 2295-2299.
M. G. N. Russell et al, N-Arylsulfonylindole Derivatives as Serotonin 50HT6 Receptor Ligands, Journal of Medicinal Chemistry 44 (2001) 3881-3895.
R. A. Glennon et al, 2-Substituted Tryptamines: Agents with Selectivity for 5-HT6Serotonin Receptors, Journal of Medicinal Chemistry 43 (2000) 1011-1018.

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