Pharmaceutical composition comprising a dual antagonist...

Details Pharmaceutical composition comprising a dual antagonist... Pharmaceutical composition comprising a dual antagonist...

2006-09-12

2006-09-12

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S307000, C514S336000, C514S352000, C514S365000, C514S367000, C514S369000, C514S370000, C514S371000, C514S378000, C514S379000, C514S393000, C514S397000, C514S406000, C514S415000, C514S419000, C514S424000, C514S427000, C514S438000, C514S443000, C514S444000, C514S445000, C514S447000, C514S448000, C514S469000, C514S471000, C514S539000, C514S562000, C514S563000, C546S147000, C546S280400, C546S309000, C548S180000, C548S188000, C548S194000, C548S195000, C548S200000, C548S204000, C548S241000, C548S247000, C548S

Reexamination Certificate

active

07105564

ABSTRACT:
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2receptor and pharmaceutical compositions comprising them.A compound of the formula (I):wherein R1is —CH2—CH═CH—CH2—CH2—CH2—COOR2or —CH═CH—CH2—CH2—CH2—COOR2; R2is hydrogen or alkyl; m is 0 or 1; p is 0 or 1; X1and X3each is independently optionally substituted aryl or optionally substituted heteroaryl; X2is a bond, —CH2—, —S—, —SO2—, —CH2—O—, —O—CH2—, —CH2—S—, —S—CH2—, or the like; X4is —CH2—, —CH2—CH2—, —C(═O)—, or the like, have a dual antagonistic activity against both a thromboxane A2receptor and a prostaglandin D2receptor.

REFERENCES:
patent: 6172113 (2001-01-01), Ohtani et al.
patent: 6384075 (2002-05-01), Ohtani et al.
patent: WO 97/00853 (1997-01-01), None
patent: WO99/15502 (1999-04-01), None
Tsuri et al., Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane Derivative: Orally Active, Potent, and Selective Prostaglandin D.sub.2 Receptor Antagonists, Journal of Medicinal Chemistry, vol. 40, No. 22, pp. 3504-3507, 1997.

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