Compounds and use thereof to modify transport across cell...

Details Compounds and use thereof to modify transport across cell... Compounds and use thereof to modify transport across cell...

2006-05-23

2006-05-23

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07049295

ABSTRACT:
The invention provides the use of a compound capable of preferential interaction with plasma membrane lipid microdomains (PMLMs) as enhancers of transport processes across endothelial, epithelial and mesothelial membranes (ie including blood-brain-blood barrier and gastrointestinal mucosal membranes). When associated with therapeutic agents, the compounds act as transport vehicles. When the compounds interact with PMLMs in such a way as to inhibit transport across the membrane, the compounds function as anti-infective agents.

REFERENCES:
patent: WO 99/36092 (1999-07-01), None
patent: WO-99/36092 (1999-07-01), None
Simons et al., “Functional Rafts in Cell Membranes,”Nature, 387:569-572 (1997).
Wall et al., “Interactions of Macromolecules with the Mammalian Cell Surface,”J. Cell. Sci., 108: 2673-2682 (1995).
Cladera et al., “Intramembrane Molecular Dipoles Affect the Membrane Insertion and Folding of a Model Amphiphilic Peptide,”Biophys., 74:2434-2442 (1998).
Cladera et al., “Characterization of the Sequence of Interactions of the Fusion Domain of the Simian Immunodeficiency Virus with Membranes,”J. Biol. Chem., 274:29951-29959 (1999).
Kupper et al., “G-Protein Activation by Interleukin-8 and Related Cytokines in Human Neutrophil Plasma Membranes,”Biochem J., 282:429-434 (1992).
Muller et al., “Functional Reconstitution of Proton-Pumping Cytochrome-c Oxidase in Phospholopids Vesicles,”Methods Enzymol, 126:78-87 (1986).

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