Non-aqueous injectable formulations for extended release of...

Details Non-aqueous injectable formulations for extended release of... Non-aqueous injectable formulations for extended release of...

2006-05-23

2006-05-23

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

Reexamination Certificate

active

07048938

ABSTRACT:
The present invention provides compositions which allow for the extended release and enhanced bioavailability of biologically-active polypeptides following parenteral delivery to an animal. More particularly, it concerns compositions comprising biologically-active somatotropin formulated for extended release, methods of preparing these compositions, and methods of using the same. These compositions comprise somatotropin, a bioavailability-enhancing constituent (BEC), and a substantially non-aqueous, hydrophobic excipient. The BEC may comprise (i) amino acids or amino acid derivatives, such as histidine-HCl; (ii) hydroxamate derivatives, such as histidine hydroxamate or suberohydroxamic acid; (iii) non-reducing carbohydrates, such as trehalose or trehalose octaacetate; (iv) oxo-acid salts, such as a mixture of monobasic and dibasic sodium phosphate; or (v) a mixture of two or more compounds from within the foregoing classes (i)–(iv).

REFERENCES:
patent: 4816568 (1989-03-01), Hamilton et al.
patent: 4857506 (1989-08-01), Tyle
patent: 4917685 (1990-04-01), Viswanathan et al.
patent: 4977140 (1990-12-01), Ferguson et al.
patent: 5034229 (1991-07-01), Magruder et al.
patent: 5037420 (1991-08-01), Magruder
patent: 5096885 (1992-03-01), Pearlman et al.
patent: 5219572 (1993-06-01), Sivaramakrishnan et al.
patent: 5356635 (1994-10-01), Raman et al.
patent: 5359030 (1994-10-01), Ekwuribe
patent: 5399489 (1995-03-01), Krivi
patent: 5438040 (1995-08-01), Ekwuribe
patent: 5474980 (1995-12-01), Mitchell
patent: 5520927 (1996-05-01), Kim et al.
patent: 5607691 (1997-03-01), Hale et al.
patent: 5612315 (1997-03-01), Pikal et al.
patent: 5631227 (1997-05-01), Harbour
patent: 5681811 (1997-10-01), Ekwuribe
patent: 5739108 (1998-04-01), Mitchell
patent: 5744163 (1998-04-01), Kim et al.
patent: 5773588 (1998-06-01), Owsley et al.
patent: 5801141 (1998-09-01), Steber
patent: 5849704 (1998-12-01), Sørensen et al.
patent: 5972370 (1999-10-01), Eckenhoff
patent: 5986073 (1999-11-01), Storrs et al.
patent: 6086918 (2000-07-01), Stern
patent: 6162258 (2000-12-01), Scarborough et al.
patent: WO 97/03692 (1997-02-01), None
patent: 0 216 485 (1987-04-01), None
patent: 0 278 103 (1988-08-01), None
patent: 0303746 (1989-02-01), None
patent: 0374120 (1990-06-01), None
patent: 0 523 330 (1993-01-01), None
patent: 913177 (1999-05-01), None
patent: 3086834 (1991-04-01), None
patent: WO 89 09614 (1989-10-01), None
patent: WO 93/12812 (1993-07-01), None
patent: WO 93/13792 (1993-07-01), None
patent: WO 93/19773 (1993-10-01), None
patent: WO 97/29767 (1997-08-01), None
patent: WO 98/29131 (1998-07-01), None
patent: WO 00/13674 (2000-03-01), None
Katakam, Manohar:Use of non-ionic surfactants to stabilize recombinant human growth hormone and to develop its sustained release formulation,DISS. ABSTR. INT., vol. 57, No. 5, 1996, p. 3149.

Affiliated with

Also associated with

Rating

Non-aqueous injectable formulations for extended release of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-aqueous injectable formulations for extended release of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-aqueous injectable formulations for extended release of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3566857