Tissue electroperforation for enhanced drug delivery

Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...

Reexamination Certificate

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C604S020000, C604S500000, C604S503000, C604S509000, C604S114000, C604S096010, C514S002600, C514S054000, C606S192000, C606S193000, C606S027000, C606S028000, C606S029000, C606S031000, C606S032000, C606S041000, C606S046000, C606S047000, C606S048000, C606S049000, C606S050000, C606S191000, C607S096000, C607S101000, C607S102000, C607S113000, C607S116000, C607S140000

Reexamination Certificate

active

07113821

ABSTRACT:
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating the membrane with an electric current from a treatment electrode; and utilizing a driving force to move the molecule through the perforated membrane.

REFERENCES:
patent: 3315665 (1967-04-01), MacLeod
patent: 3950158 (1976-04-01), Gossett
patent: 3964482 (1976-06-01), Gerstel et al.
patent: 4230105 (1980-10-01), Harwood
patent: 4406658 (1983-09-01), Lattin et al.
patent: 4655766 (1987-04-01), Theeuwes et al.
patent: 4685911 (1987-08-01), Konno et al.
patent: 4767402 (1988-08-01), Kost et al.
patent: 4790824 (1988-12-01), Morrow et al.
patent: 4963360 (1990-10-01), Argaud
patent: 5013293 (1991-05-01), Sibalis
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5036861 (1991-08-01), Sembrowich et al.
patent: 5042975 (1991-08-01), Chien et al.
patent: 5135478 (1992-08-01), Sibalis
patent: 5156591 (1992-10-01), Gross et al.
patent: 5213568 (1993-05-01), Lattin et al.
patent: 5224927 (1993-07-01), Tapper
patent: 5250023 (1993-10-01), Lee et al.
patent: 5279543 (1994-01-01), Glikfeld et al.
patent: 5279544 (1994-01-01), Gross et al.
patent: 5320607 (1994-06-01), Ishibashi
patent: 5362307 (1994-11-01), Guy et al.
patent: 5386837 (1995-02-01), Sterzer
patent: 5399163 (1995-03-01), Peterson et al.
patent: 5438984 (1995-08-01), Schoendorfer
patent: 5441490 (1995-08-01), Svedman
patent: 5527288 (1996-06-01), Gross et al.
patent: 5533971 (1996-07-01), Phipps
patent: 5540669 (1996-07-01), Sage, Jr. et al.
patent: 5582586 (1996-12-01), Tachibana et al.
patent: 5591124 (1997-01-01), Phipps
patent: 5607691 (1997-03-01), Hale et al.
patent: 5614502 (1997-03-01), Flotte et al.
patent: 5636632 (1997-06-01), Bommannan et al.
patent: 5658853 (1997-08-01), Kassebaum et al.
patent: 5658892 (1997-08-01), Flotte et al.
patent: 5662624 (1997-09-01), Sundstrom et al.
patent: 5667491 (1997-09-01), Pliquett et al.
patent: 5718955 (1998-02-01), McGuire et al.
patent: 5730714 (1998-03-01), Guy et al.
patent: 5779698 (1998-07-01), Clayman et al.
patent: 5853383 (1998-12-01), Murdock
patent: 5857992 (1999-01-01), Haak et al.
patent: 5885211 (1999-03-01), Eppstein et al.
patent: 5964726 (1999-10-01), Korenstein et al.
patent: 5983131 (1999-11-01), Weaver et al.
patent: 6050988 (2000-04-01), Zuck
patent: 6083196 (2000-07-01), Trautman et al.
patent: 6104952 (2000-08-01), Tu et al.
patent: 6132755 (2000-10-01), Eicher et al.
patent: 6148232 (2000-11-01), Avrahami
patent: 6149620 (2000-11-01), Baker et al.
patent: 6175752 (2001-01-01), Say et al.
patent: 6527716 (2003-03-01), Eppstein
patent: 6611706 (2003-08-01), Avrahami et al.
patent: 6615079 (2003-09-01), Avrahami
patent: 2001/0023330 (2001-09-01), Palti
patent: 195 25 607 (1997-01-01), None
patent: 0 429 842 (1991-06-01), None
patent: 2 303 208 (1997-02-01), None
patent: 86/07269 (1986-12-01), None
patent: 92/07618 (1992-05-01), None
patent: 93/17754 (1993-09-01), None
patent: 94/23777 (1994-10-01), None
patent: 95/30410 (1995-11-01), None
patent: 96/17648 (1995-11-01), None
patent: 96/00110 (1996-01-01), None
patent: 96/37256 (1996-11-01), None
patent: WO 97/04832 (1997-02-01), None
patent: 97/12644 (1997-04-01), None
patent: WO 97/48440 (1997-12-01), None
patent: 97/48441 (1997-12-01), None
patent: 97/48442 (1997-12-01), None
patent: 98/11937 (1998-03-01), None
patent: 98/28037 (1998-07-01), None
patent: 98/28038 (1998-07-01), None
patent: WO 98/29134 (1998-07-01), None
patent: 98/46124 (1998-10-01), None
patent: WO 00/69515 (2000-11-01), None
patent: WO 01/13989 (2001-03-01), None
Banga et al., Assessing the potential of skin electroporation for the delivery of protein- and gene-based drugs, 1998, Tibtech, vol. 16, pp. 408-412.
Verma et al., Gene therapy- promises, problems and prospects, 1997, Nature, vol. 3879, pp. 239-242.
Anderson, Human gene therapy, 1998, Nature, vol. 392, pp. 25-30.
Brand et al., An experimental model for interpreting percutaneous penetration of oligonucleotides that incoporates the role of keratinocytes, 1998, The Journal of Investigative Dermatology, vol. 111, pp. 1166-1171.
Henry et al., Microfabricated microneedles: A novel approach to transdermal drug delivery, 1998, Journal of Pharmaceutical Sciences, vol. 87, pp. 922-925.
Sun, Y. Skin Absorption Enhancement by Physical Means: Heat, Ultrasound, and Electricity. Transdermal and Topical Drug Delivery Systems. (1997) 327-355.
Buyuktimkin N., Buyuktimkin S. Chemical Means of Transdermal Drug Permeation Enhancement. Transdermal and Topical Drug Delivery Systems. (1997) 357-475.
Sun Y., Liu J.C., Xue H. Important Parameters Affecting Iontophoretic Transdermal Delivery of Insulin. Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 17, Controlled Release Society, Inc. (1990) 202-203.
Roberts M. Lai P., Cross S., Yoshida N. Solute Structure as a Determinant of Iontophoretic Transport. Mechanisms of Transdermal Drug Delivery. (1997) 291-349.
Burdick, K., Electrosurgical Apparatus and Their Application in Dermatology, Charles C. Thomas (1966) pp. 2-60.
Pikal, M., The Role of Electroosmotic flow in transdermal iontophoresis, Advanced Drug Delivery Review, 9(1992) pp. 201-237.
Zakzewski, C., Li, J., Amory, D., Jensen, J., Kalatzis-Manolakis, E., Design and implementation of a constant-current pulsed iontophoretic stimulation device, Captopril, Sigma Chemical Co., St. Louis, Missouri, (1996) pp. 484-488.
Jaw, F., Wang, C., Huang, Y., Portable current stimulator for transdermal iontophoretic drug delivery, Med. Eng. Phys. vol. 17, No. 5, (1995)pp. 385-386.
Park, M.R., Constant current source for iontophoresis, Journal of Neuroscience Methods, 29 (1989) pp. 85-89.
Pollack, S., Electrosurgery, Dermatology, Ed. S.L. Moschella and H.J. Hurley, (W.B. Saunders Company, 1992), pp. 2419-2431.
Sebben, J., Cutaneous Electrosurgery, Year Book Medical Publishers, Inc. 1989, pp. 1-211.

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