Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-09-05
2006-09-05
Collins, Cynthia (Department: 1638)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S468000, C536S023530, C800S288000
Reexamination Certificate
active
07101688
ABSTRACT:
The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.
REFERENCES:
patent: 4704692 (1987-11-01), Ladner
patent: 4956282 (1990-09-01), Goodman et al.
patent: 5639947 (1997-06-01), Hiatt et al.
patent: 5959177 (1999-09-01), Hein et al.
patent: 6303341 (2001-10-01), Hiatt et al.
patent: 6417429 (2002-07-01), Hein et al.
patent: 0273889 (1988-07-01), None
patent: WO 87/00865 (1987-02-01), None
patent: WO 90/08829 (1990-08-01), None
patent: WO 90/08830 (1990-08-01), None
U.S. Appl. No. 10/781,989, filed Feb. 2004, Hiatt et al.
Lippincott-Schwartz J. et al. Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins. Cell. Jul. 15, 1988;54(2):209-20.
Waldmann R. et al. Molecular cloning and functional expression of a novel amiloride-sensitive Na+channel. J Biol Chem. Nov. 17, 1995;270(46):27411-4.
Bonifacino J.S. et al. Pre-Golgi degradation of newly sunthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J Cell Biol. Jul. 1989;109(1):73-83.
Yu L. et al. Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits. J Biol Chem. Oct. 24, 1997;272(43):27288-94.
Aizpurua, et al., “Oral vaccinations: identification of classes of proteins that provoke an immune response upon oral feeding,”Journal of Experimental Medicine, 167:440-451 (1988).
Bahou, et al., “A monoclonal antibody to von Willebrand Factor (vWF) inhibits Factor VIII binding,”The Journal of Clinical Investigation, 84(1):56-61 (1989).
Beachy, et al., “Accumulation and assembly of soybean β-conglycinin in seeds of transformed petunia plants,”EMBO J., 4:3047-3053 (1985).
Benson, et al., “A multispecies enzyme-linked immunosorbent assay for von Willebrand factor,”The Journal of Laboratory and Clinical Medicine, 119(4):420-427 (1992).
Benson, et al., “A sensitive immunoassay for von Willebrand factor,”The Journal of Immunoassay, 12(3):371-390 (1991).
Brinkhous, et al., “Determinations of von Willebrand Factor activity elicited by ristocetin and botrocatin: studies on a human von Willebrand factor-binding antibody,”Semin. Thromb. Hemost., 11(4):337-341 (1985).
Chand, et al., “A two-site, monoclonal antibody-based immunoassay for von Willebrand Factor demonstration that vWF function resides in a conformational epitope,”Thromb. Haemostasis, 55(3):318-324 (1986).
Cocking, et al., “Gene transfer in cereals,”Science, 236:1259-1262 (1987).
During, et al., “Synthesis and self-assembly of a functional monoclonal antibody in transgenicNicotiana tabacum,” Plant Molecular Biology, 15:281-293 (1990).
During, et al., “Synthesis, assembly and targeting of foreign chimeric proteins in transgenicNicotiana tabacumcells,”Biol. Chem. Hoppe-Seyler, 370:888 (1989).
During, et al., “Wound-Inducible Expression and Secretion of T4 Lysozyme and Monoclonal Antibodies inNicotiana tabacum,” Thesis, Univ. Koln, (1988).
Gatz, et al., “Tn10-encoded tet repressor can regulate an operator-containing plant promoter,”Proc. Natl. Acad. Sci., 85:1394-1397 (1988).
Harpster, et al., “Relative strengths of the 35S cauliflower mosaic virus, 1′,2′, and nopaline synthase promoters in transformed tobacco sugarbeet and oilseed rape callus tissue,”Mol. Gen. Genet, 212:182-190 (1988).
Hein, et al., “Evaluation of immunoglobulins from plant cells,”Biotechnol., 7:455-461 (1991).
Hiatt, et al., “Antibodies produced in plants,”Nature, pp. 469-470 (1990).
Hiatt, et al., “Monoclonal antibody engineering in plants,”FEBS Letters, 307(1):71-75 (1992).
Hiatt, et al., “Production of antibodies in transgenic plants,”Nature, 342:76-78 (1989).
Hofte & Whiteley, “Insecticidal Crystal Proteins ofBacillus thuringiensis,” Microbiological Reviews, 53(2):242-255 (1989).
Horsch, et al., “A simple and general method for transferring genes into plants,”Science, 227:1229-1231 (1985).
Iturriaga, et al., “Endoplasmic Reticulum Targeting and Glycosylation of Hybrid Proteins in Transgenic Tobacco,”The Plant Cell, 1:381-390 (1989).
Jefferson, et al., “GUS fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants,”EMBO Journal, 6(13):3901-3907 (1987).
Kavanaugh, et al., “Targeting a foreign protein to chloroplasts using fusions to the transit peptide of a chlorophyll a/b protein,”Mol. Gen Genet, 215:38-45 (1988).
Kusnadi, et al., “Production of Recombinant Proteins in Transgenic Plants: Practical Considerations,”Biotechnology and Bioengineering, 56(5):473-484 (1997).
Mascelli, et al., “Proteolytic studies on the structure of bovine von Willebrand Factor,”Biochemistry, 27(4):1274-1284 (1988).
Merryweather, et al., “Control of plant gene expression using wild=type and aletred specificity bacterial repressor molecules,”Journal of Cellular Biochemistry Supplement, 13d:307 (1989).
Pietu, et al., “Localization within the 106-N-terminal amino acids of von Willebrand Factor (vWF) of the epitope corresponding to a monoclonal antibody which inhibits vWF binding to factor VIII,”Biochemical and Biophysical Research Communications, 163(1):618-626 (1989).
Silverman, et al., “Modification of the platelet-binding domain of von Willebrand Factor,”The Journal of Laboratory and Cliinical Medicine, 110(1):117-118 (1987).
Thorens, et al., “Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion,”Nature, 321:618-620 Abstract No. 6216213 (1986).
Thorsen, et al., “Identification of Platelet antigens by monoclonal antibodies using crossed immunoelectrophoresis with immuno-blotting of monoclonal antibody,”Throm. Haemostasis, 57(2):212-216 (1984).
Verweij, et al., “Full-length von Willebrand Factor (vwF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit,” 5(8):1839-1847 (1986).
Bonifacino et al., “Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains : intrinsic sensitivity and the role of subunit assembly.” J.Cell.Biol., Jul. 1989, 109:73-83.
Lippincott-Schwartz et al., “Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins.” Cell, 54:209-220, 1988.
Waldmann et al., “Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.” Journal of Biological Chemistry, 270:27411-27414, 1995.
Yu et al., “Biosynthesis of the phagocyte NADPH oxidase cytochrome558.” Journal of Biological Chemistry, 272:27288-27294, 1997.
Bird, R.E. et al., Single-chain Antigen-binding Proteins: Science; Oct. 21, 1988:242(4877):423-6.
Huston, J.S., Antigen Recognition and Targeted Delivery by the Single-chain Fv; Cell Biophys. Jan.-Jun. 1993:22(1-3): 189-224.
Graf L. et al., Mitochondrial Import of Rat Pre-omithine Transcarbamylase: Accurate Processing of the Precursor Form is not Required for Uptake into Mitochondria, Nor Assembly into Catalytically Active Enzyme: Protein Eng. Oct. 1988:2(4):297-3.
Hein Mich B.
Hiatt Andrew C.
Collins Cynthia
Foley & Lardner LLP
The Scripps Research Institute
Wilson Barry S.
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