Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-31
2006-01-31
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S278000, C540S522000, C540S543000, C546S016000, C546S018000
Reexamination Certificate
active
06992077
ABSTRACT:
One aspect of the present invention relates to spirocyclic compounds. Another aspect of the present invention relates to the use of the spirocyclic compounds as ligands for mammalian G-protein-coupled receptors or sigma receptors. The present invention also relates to methods of modulating the activity of a G-protein-coupled receptor or a sigma receptor in a mammal using the spirocyclic compounds of the present invention. The present invention also relates to methods of treating various diseases in a mammal using the spirocyclic compounds of the present invention.
REFERENCES:
patent: 5434158 (1995-07-01), Shah
patent: 5763471 (1998-06-01), Fourtillan et al.
patent: WO 96/05203 (1996-02-01), None
Brown et al.; “The Synthesis of Antioxidants Showing Selective Affinity for Low Density Lipoproteins”, J. Chem. Soc. Perkin Trans., 1:2329-2336 (1997).
Cossy et al.; “Synthesis of Spiro[Quinoline-2,4'-Piperidines]”, Tetrahedron Letters 39:2965-2968 (1998).
Cossy et al.; “Synthesis of Spiro[benzazepine-2,4'-piperidine]”, J. Org. Chem. 63: 4554-4557 (1998).
Cossy et al.; Heck Reaction versus Free Radical Reaction for the Synthesis of Spiro[indoline-2,4'-piperidines], Synlett, pp. 251-252 (March 1998).
Ganapathy et al.; “Molecular and Ligand -Binding Characterization of the o-Receptor in the Jurkat Human T Lymphocyte Cell Line1”, The Journal of Pharmacology and Experimental Therapeutics, 289(1): 251-260 (1999).
Quaglia, W. et al., “1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine](Spipethiane), a Potent and Highly Selective σ, Ligand”, Journal of Medicinal chemistry 41(10): 1557-1560 (May 7, 1998).
Sulsky et al.; “Conformational Switching and the Synthesis of Spiro[2H-indol]-3(1H)-ones by Radical Cyclization”, J. Org. Chem. 64: 5504-5510 (1999).
Hauske James R.
Persons Paul E.
Radeke Heike
Foley & Hoag LLP
Gordon Dana M.
Kifle Bruck
Sepracor Inc.
LandOfFree
Spirocyclic ligands for sigma receptors, and libraries and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Spirocyclic ligands for sigma receptors, and libraries and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spirocyclic ligands for sigma receptors, and libraries and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3564604