Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-07-11
2006-07-11
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C435S810000, C536S022100, C536S024300
Reexamination Certificate
active
07074561
ABSTRACT:
The present invention is directed to isothermal transcription based assays for the detection and quantification of alpha-fetoprotein (AFP) mRNA. The present invention is also directed to oligonucleotides for amplifying AFP mRNA and probes for use in the detection and quantification of the amplification product. The present invention is also directed to detecting hepatocellular carcinoma, metastasis thereof and tumor recurrence by analyzing peripheral blood for the presence of AFP mRNA.
REFERENCES:
patent: 5409818 (1995-04-01), Davey et al.
patent: 5554516 (1996-09-01), Kacian et al.
patent: 5554527 (1996-09-01), Fickenscher
patent: 6093542 (2000-07-01), Romano et al.
patent: 6121023 (2000-09-01), Romano et al.
patent: 195 09 169 (1996-09-01), None
patent: 0408295 (1996-08-01), None
patent: 88/10315 (1998-12-01), None
Wong et al. “Circulating Tumor Cell mRNAs in Peripheral Blood from Hepatocellular Carcinoma Patients Under Radiotherapy, Surgical Resection or Chemotherapy: A Quantitative Evaluation,”Cancer Letters, vol. 167, pp. 183-191 (2001).
Wong et al. “Hematogenous Dissemination of Hepatocytes and Tumor Cells after Surgical Resection of Hepatocellular Carcinoma: A Quantitative Analysis,”Clincal Cancer Research, vol. 5, pp. 4021-4027 (1999).
Jiang et al., “Detection of Alphafetoprotein-Expressing Cells in the Blood of Patients with Hepatoma and Hepatitis,”British Journal of Cancer, vol. 75(6), pp. 928-933 (1997).
Wong et al., “Quantitative Comparison of Alpha-Fetoprotein and Albumin mRNA Levels in Hepatocellular Carcinoma/Adenoma, Non-tumor Liver and Blood: Implications in Cancer Detection and Monitoring,”Cancer Letters, vol. 156, pp. 141-149 (2000).
Poon et al., “Application of Classification Tree and Neural Network Algorithms to the Identification of Serological Liver Marker Profiles for the Diagnosis of Hepatocellular Carcinoma,”Oncology, vol. 61, pp. 275-283 (2001).
Lee Eun Mi
Shurtliff Roxanne N.
bioMerieux Inc.
Horlick Kenneth R.
Patel, Esq. Samir R.
Tung Joyce
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