Process for preparing inhibitors of nucleoside metabolism

Details Process for preparing inhibitors of nucleoside metabolism Process for preparing inhibitors of nucleoside metabolism

2006-04-04

2006-04-04

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S224000, C544S242000

Reexamination Certificate

active

07022852

ABSTRACT:
A process of preparing a compound of the formula (I)wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof,which comprises reacting a compound of the formula (II)with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX),to form a compound of formula (XX)The compound of formula (LXX) is N- and O-deprotected to obtain the compound of formula (I).

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