Process for making chiral 1,4-disubstituted piperazines

Details Process for making chiral 1,4-disubstituted piperazines Process for making chiral 1,4-disubstituted piperazines

2006-03-28

2006-03-28

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S394000

Reexamination Certificate

active

07019137

ABSTRACT:
A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula:wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.

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