Process for producing modified cyclodextrins

Details Process for producing modified cyclodextrins Process for producing modified cyclodextrins

1986-04-16

1990-04-24

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536112, 536120, 536124, A61K 100

Patent

active

049202146

ABSTRACT:
The present invention is directed to a process for modifying and increasing the water solubility of cyclodextrins in a moderate controlled progressive reaction and in particular to producing derivatives of cyclodextrins in a substantially anhydrous reaction with an alkylene carbonate such as ethylene carbonate in an alkaline environment.

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Grobelny, D., "A New Method of Synthesis of Beta-Haloethylbenzyl Ethers", Tetrahedron Letters, No. 28, 1979, p. 2639.
Ullmanns Encyklopaedie der technischen Chemie, 9th Ed., Munchen, Urban & Schwarzenberg, 1957, p. 777.
Pitha, J. and Pitha, J., "Amorphous Water-Soluble Derivatives of Cyclodextrins: Nontoxic Dissolution Enhancing Excipients", J. of Pharmaceutical Sci., vol. 74, No. 9, Sep. 1985, pp. 987-990.
Muller, B. and Brauns, U., "Solubilization of Drugs by Modified Beta-Cyclodextrins", Int. J. of Pharmaceutics, 26 (1985), pp. 77-88.
Texaco Chemical Co., Ethylene Carbonate Propylene Carbonate.
Srivastava, H. et al., "Studies on )-(2-Hydroxyethyl) Ethers of Carbohydrates: Part II-Hydroxyethylation of Carbohydrates with Ethylene Carbonate" Indian J. of Chemistry, vol. 9, Oct. 1971, pp. 1081-1082.

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