Bispecific molecules recognizing lymphocyte antigen CD2 and tumo

Details Bispecific molecules recognizing lymphocyte antigen CD2 and tumo Bispecific molecules recognizing lymphocyte antigen CD2 and tumo

1994-08-02

1998-08-25

Loring, Susan R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

5303873, 5303882, 53038822, 53038875, 53038823, 5303888, 53038885, C12P 2108, C07K 1628, C07K 1630, C07K 1600

Patent

active

057982295

ABSTRACT:
The present invention relates to novel and highly effective bispecific antibody fragments which recognize lymphocyte CD2 antigen and any variable tumor antigen. Moreover, the invention relates to two new monoclonal antibodies terms AICD2.M1 and AICD2.M2. A combination of these antibodies, whereby at least one of them is a bispecific antibody fragment, can be used successfully in tumor therapy and diagnostics.

REFERENCES:
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Petersen, A. et al., Nature, 329: 842-846, Oct. 29, 1987.
Thurin, J. et al, Cancer Research, 47:1229-1233, Mar. 1, 1987.
Reinder L. H. Bolhuis, Els Sturm, and Eric Braakman, Dept. of Immunology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands, "T Cell Targeting in Cancer Therapy", Cancer Immunology Immunotherapy, Springer-Verlag 1991, pp. 1-8.
"Letters to Nature", Nature, vol. 314, 18 Apr. 1985, pp. 628-633.
Tutt, et al., The Journal of Immunology, "Trispecific F(ab').sub.3 Derivatives that use Cooperative Signaling via the TCR/CD2 Complex and CD2 to Activate and Redirect Resting Cytotoxic T Cells", vol. 147, No. 1, Jul. 1, 1991. pp. 60-69.
M. Wild, et al., Immunobiology, "T Cell Targeting by Anti-CD2 X Anti-EGR-R Bispecific Antibodies", vol. 189, No. 1-2, Sep. 30, 1993, p. 165, abstract K.25.
C. Jaggle, et al., Immunobiology, "Bispecific Antibodies of Targeted Cellular Cytotoxicity", vol. 189, No. 1-2, Sep. 30, 1993, pp. 155-156, abstract K.9.
H. Bernhard, et al., International Journal of Cancer, "Induction of Tumor-Cell Lysis by Bi-Specific Antibody Recognizing Ganglioside GD2 and T-cell Antigen CD3", vol. 55, No. 3, Sep. 30, 1993, pp. 465-470.

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