Propanolamine derivative having 1, 4-benzodioxane ring

Details Propanolamine derivative having 1, 4-benzodioxane ring Propanolamine derivative having 1, 4-benzodioxane ring

2006-04-04

2006-04-04

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S362000

Reexamination Certificate

active

07022732

ABSTRACT:
This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof:The present compound is represented by the above formula wherein R1-3may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1–C6)alkyl group, a (C1–C6)alkoxy group, a (C1–C6)alkylsulfonamido group, or a phenyl group; R4-5each represents a hydrogen atom or a (C1–C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring.This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.

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W. J. Rzeszotarski et al., “Cardioselectivity of β-adrenoceptor blocking agents. 2. Role of the amino group substituent”, Journal of Medical Chemistry, (1983), vol. 26, No. 5, pp. 644-648; especially, table II.

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