Method for providing a substrate structure for oriented...

Stock material or miscellaneous articles – Liquid crystal optical display having layer of specified...

Reexamination Certificate

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C428S001200, C428S473000, C607S050000

Reexamination Certificate

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07041343

ABSTRACT:
The invention relates to a method for providing a substrate structure for oriented neurite outgrowth, wherein a basic substrate is provided, characterized in that at least one alignment layer is deposited on said substrate and a mono- or multi-layer of a liquid crystal material is deposited on said at least one alignment layer or a combined alignment layer is deposited on said substrate, thereby providing a structured surface.

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Yasuhiko Jimbo et al: “Electrical Stimulation of Cultured Neutral Cells by Planar Electrode Array” Proceedings of the Annual Conference of the Engineering in Medicine and Biology Society, US, New York, IEEE, vol. Conf. 12, p. 1741-1742, XP000239375.
Yasuhiko Kimbo et al: “Simultaneous Measurement of Intracellular Calcium and Electrical Activity From Patterned Neural Networks in Culture” IEEE Transactions on Biomedical Engineering, US, IEEE, Inc. New York, vol. 40, No. 8, p. 804-810, XP000418557.
Kleinfeld D et al: “Controlled Outgrowth of Dissociated Neurons on Patterned Substrates”, J Neurosci, vol. 8, No. 11, 1988, pp. 4098-4120, XP000915297.
Patent Abstracts of Japan, vol. 0185, No. 22, Sep. 30, 1994, JP 06 180455, Jun. 28, 1994.

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