Substituted isoxazolines and their use as antibacterial agents

Details Substituted isoxazolines and their use as antibacterial agents Substituted isoxazolines and their use as antibacterial agents

2006-07-25

2006-07-25

Raymond, Richard (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S243000, C548S244000, C548S245000, C544S333000, C546S209000, C546S272100, C514S256000, C514S275000, C514S326000, C514S340000, C514S378000, C514S380000

Reexamination Certificate

active

07081538

ABSTRACT:
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2: R2and R3are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, R13CO—, R13SO2— or R13CS—; wherein R13is, for example, optionally substituted (1–10C)alkyl or R14C(O)O(1–6C)alkyl wherein R14is optionally substituted (1–10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described

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