Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2006-05-02
2006-05-02
Casler, Brian L. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S407000, C600S473000, C600S475000, C600S476000, C600S477000, C600S478000, C356S301000, C356S303000, C606S002000, C606S003000, C606S004000, C606S010000
Reexamination Certificate
active
07039452
ABSTRACT:
A method and apparatus are provided for Raman imaging of carotenoids and related chemical substances in biological tissue, such as macular pigments. The method and apparatus utilize the technique of resonance Raman spectroscopy to produce an image of the levels of carotenoids and similar substances in tissue. In this technique, light is directed upon the area of tissue which is of interest such as the retina of an eye. A small fraction of the scattered light is scattered inelastically, producing a carotenoid Raman signal which is at a different frequency than the incident light. The Raman signal is collected, filtered, and analyzed to determine the spatial position and intensity of the Raman signals in the inelastically scattered light. An image of the Raman signals is then produced on an output device, with the image representing the spatial distribution and concentration level of carotenoids in the tissue.
REFERENCES:
patent: 4144464 (1979-03-01), Loree et al.
patent: 4318057 (1982-03-01), Buchwald et al.
patent: 4500995 (1985-02-01), White
patent: 4758081 (1988-07-01), Barnes
patent: 4807240 (1989-02-01), Goldstone
patent: 4832483 (1989-05-01), Verma
patent: 4852579 (1989-08-01), Gilstad et al.
patent: 4858238 (1989-08-01), Cardimona
patent: 5034228 (1991-07-01), Meybeck et al.
patent: 5124313 (1992-06-01), Schaeffer et al.
patent: 5243983 (1993-09-01), Tarr et al.
patent: 5275168 (1994-01-01), Reintjes et al.
patent: 5290605 (1994-03-01), Shapira
patent: 5303026 (1994-04-01), Strobl et al.
patent: 5304170 (1994-04-01), Green
patent: 5346488 (1994-09-01), Prince et al.
patent: 5348018 (1994-09-01), Alfano et al.
patent: 5418797 (1995-05-01), Bashkansky et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5432610 (1995-07-01), King et al.
patent: 5451785 (1995-09-01), Faris
patent: 5452723 (1995-09-01), Wu et al.
patent: 5553616 (1996-09-01), Ham et al.
patent: 5556612 (1996-09-01), Anderson et al.
patent: 5567628 (1996-10-01), Tarcha et al.
patent: 5579773 (1996-12-01), Vo-Dinh et al.
patent: 5590660 (1997-01-01), MacAulay et al.
patent: 5643623 (1997-07-01), Schmitz et al.
patent: 5657754 (1997-08-01), Rosencwaig
patent: 5697373 (1997-12-01), Richards-Kortum et al.
patent: 5733507 (1998-03-01), Zakim
patent: 5873831 (1999-02-01), Bernstein et al.
patent: 6205354 (2001-03-01), Gellermann et al.
patent: 6690966 (2004-02-01), Rava et al.
patent: 2003/0004419 (2003-01-01), Treado et al.
patent: 0 722 692 (1996-07-01), None
patent: WO 92/10131 (1992-06-01), None
patent: WO 92/15008 (1992-09-01), None
Brody, J.E., “Health Factor in Vegetables Still Elusive,” The New York Times, Section C, p. 1, Feb. 21, 1995.
Bone, R.A., Landrum, J.T., and Cains, A, “Optical Density Spectra of the Macular Pigment In Vivo and In Vitro,” Vision Res., vol. 32, No. 1, pp. 105-110, 1992.
Handelman, G.J., Snodderly, D.M., Krinsky, N.L., Russett, M.D., and Adler, A.J., “Bilogical Control of Primate Macular Pigment,” Inv. Ophthalmol. Vis. Sci., vol. 32, No. 2, pp. 257-267, Feb., 1991.
Hammond, B.R., Fuld, K., and Curran-Celentano, J., “Macular Pigment Density in Monozygotic Twins,” Invest. Ophthalmoo. Vis. Sci., vol. 36, No. 12, pp. 2531-2541, Nov., 1995.
Seddon, J.M., Ajani, U.A., Sperduto, R.D., Hiller, R., Blair, N., Burton, T.C., Farber, M.D., Gragoudas, E.S., Haller, Jr., Miller, D.T., Yannuzzi, L.A., and Willet, W., “Dietary Carotenoids, Vitamins A, C and E, and Advanced Age-Related Macular Degneration,” J. Am. Med. Assoc., vol. 272, No. 18, pp. 1413-1420, Nov. 9, 1994.
Schalch, Wolfgang, “Carotenoids in the Retina—A Review of Their Possible Role in Preventing or Limiting Damage Caused by Light and Oxygen,” Free Radicals and Aging, Basel, Switzerland: Birkhauser Verlag, pp. 280-298, 1992.
Tom C. Bakker Schut; Gerwin J. Puppels; Yvonne M. Kraan; Jan Greve; Louis L.J. Van Der Maas; and, Carl G. Figdor, “Intracellular Carotenoid Levels Measured by Raman Microspectroscopy: Comparison of Lymphocytes from Lung Cancer Patients and Healthy Individuals,” Int. J. Cancer (Pred. Oncol): 74, 20-25 (1997).
Monika Gniadecka; Hans C. Wulf; Ole F. Nielsen; Daniel H. Christensen; and, Jana Hercogova, “Distinctive Molecular Adnormalities in Benign and Malignant Skin Lesions: Sutdies by Raman Spectroscopy,” Photochemistry and Photobiology, 1997, 66(4): 418-423.
Christopher J. Frank; Douglas C.B. Redd; Ted S. Gansler; and, Richard L. McCreery, “Characterization of Human Breast Biopsy Specimens with Near-IR Raman Spectroscopy,” Anal. Chem. 1994, 66, 319-326.
Berendshot, Tos T. J. M., et al., “Influence of Lutein Supplementation on Macular Pigment, Assessed with Two Objective Techniques,” IOVS, Oct. 2000, vol. 41, No. 11, pp. 3322-3326.
Elsner, Ann E., et al, “Foveal Cone Photopigment Distribution: Small Alterations Associated witih Macular Pigment Distribution,” IOVS, Nov. 1998, vol. 39, No. 12, pp. 2394-2404.
Bernstein Paul S.
Gellermann Werner
McClane Robert W.
Casler Brian L.
Holme Roberts & Owen LLP
Roy Baisakhi
The University of Utah Research Foundation
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