Surgery – Miscellaneous – Methods
Patent
1994-10-21
1997-04-15
Nucker, Christine M.
Surgery
Miscellaneous
Methods
514 2, 514 8, 514 12, 514 21, 514 23, A61B 1900, A61K 3800
Patent
active
056200137
ABSTRACT:
A method for destroying residual lens epithelial cells in an eye in order to prevent the occurrence of posterior chamber opacification. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the lens capsule. The solution is maintained in the lens capsule for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes within the lens capsule. The solution is then removed from the lens capsule, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the lens capsule, thereby exposing residual lens epithelial cells disposed on the basement membrane to the cytotoxic agent.
REFERENCES:
patent: 4432751 (1984-02-01), Emery et al.
patent: 4515794 (1985-05-01), Emery et al.
patent: 4657930 (1987-04-01), Emery et al.
patent: 4847240 (1989-07-01), Ryser et al.
patent: 4871350 (1989-10-01), Lam et al.
patent: 4918165 (1990-04-01), Soll et al.
patent: 5055291 (1991-10-01), Lam et al.
patent: 5202252 (1993-04-01), Emery et al.
patent: 5273751 (1993-12-01), Dubroff
"Biphasic Effect of the Mitotoxin bFGF-Saporin on Bovine Lens Epithelial Cell Growth: Effect of Cell Density and Extracellular Matrix", Thierry David, Jacqueline Tassin, Douglas A. Lappi, Andrew Baird, Yves Courtois, Journal of Cellular Physiology, 1992, pp. 483-490.
"Inhibition of Proliferating Lens Epithelium with Antitransferrin Receptor Immunotoxin", Kenneth M. Goins, MD; Julio R. Ortiz, MD; Sam F. A. Fulcher, MD; James T. Handa, MD; Glenn J. Jaffe, MD; Gary N. Foulks, MD; L. Michael Cobo, MD; J. Cararact Refract Surg, vol. 20, Sep. 1994, pp. 513-516.
Merck Manual, Fifteenth Ed., Merck & Co., Rahway, NJ, 1987. see pp. 1120-1121.
American Cyanamid Company
Nucker Christine M.
Prickril Benet
Smith Montgomery W.
Vacca Rita D.
LandOfFree
Method for destroying residual lens epithelial cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for destroying residual lens epithelial cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for destroying residual lens epithelial cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-354431