Substituted imidazole derivatives: GABAA receptor ligands

Details Substituted imidazole derivatives: GABAA receptor ligands Substituted imidazole derivatives: GABAA receptor ligands

Filed on

2006-04-18

Date issued

2006-04-18

Examiner

Stockton, Laura L. (Department: 1626)

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

C514S397000, C548S314400, C546S274100

Type

Reexamination Certificate

Status

active

Patent number

07030144

Description

ABSTRACT:
Substituted imidazole derivatives that bind to GABAAreceptors are provided. Such compounds may be used to modulate ligand binding to GABAAreceptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAAreceptors (e.g., receptor localization studies).

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Mohr et al., Clinical Neuropharmacology, (1986), vol. 9, No. 3, pp. 257-263.
Thomas et al., (1981), J. Bio. Chem., 156:9838-9842.
White et al., (1995), NeuroReport, 6:1313-1316.
White, et al., (1995) Receptors and Channels 3:1-5.
International Search Report for International Application PCT/US 03/13855, Aug. 20, 2003.

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