Microfluidic devices incorporating improved channel geometries

Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus

Reexamination Certificate

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C204S604000, C204S451000, C204S453000, C422S068100, C422S091000, C422S105000, C435S287100, C435S287300, C435S288500

Reexamination Certificate

active

07033474

ABSTRACT:
The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.

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Effenhauser, C.S. et al., “Glass Chips for High-Speed Capillary Electrophoresis Separations with Submicrometer Plate Heights,”Anal. Chem.65:2637-2642 (1993), month not available.
Effenhauser, C.S. et al., “High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device,”Anal. Chem.66:2949-2953 (1994), month not available.
Fan, Z.H. et al., “Micromachining of Capillary Electrophoresis Injectors and Separators on Glass Chips and Evaluation of Flow at Capillary Intersections,”Anal. Chem.66:177-184 (1994), month not avaiable.
Ghandhi, S.K. et al.,VLSI Fabrication Principles, John Wiley & Sons, New York, Chapter 10 (1994), month not available.
Harrison, D.J. et al., “Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip,”Science261:895-897 (1993), month not available.
Jacobson, S.C. et al., “Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices,”Anal Chem.66:1107-1113 (1994), month not available.
Jacobson, S.C. et al., “High-Speed Separations on a Microchip,”Anal. Chem.66:1114-1118 (1994), month not avaiable.
Jacobson, S.C. et al., “Open Channel Electrochromatography on a Microchip,”Anal. Chem.66:2369-2373 (1994), month not available.
Jacobson, S.C. et al., “Precolumn Reactions with Electrophoretic Analysis integrated on a Microchip,”Anal. Chem.66:4127-4132 (1994), month not available.
Jacobson, S.C. et al., “Fused Quartz Substrates for Micr

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