Amino-functionalized 1,2,4-trioxanes useful as antimalarial...

Details Amino-functionalized 1,2,4-trioxanes useful as antimalarial... Amino-functionalized 1,2,4-trioxanes useful as antimalarial...

2006-07-04

2006-07-04

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S333000

Reexamination Certificate

active

07071226

ABSTRACT:
The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula 4wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents phenyl, 4-methoxyphenyl, 4-chlorophenyl, 3,5-dichlorophenyl, 4-acetylaminophenyl, 1-naphthyl, 2-biphenyl, 4-biphenyl, 2-fluorene, 4-fluorophenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl and 4-trifluoromethylphenyl and the like.

REFERENCES:
Singh et al, Bioorganic & Medicinal Chemistry Letters, 14(2), p. 459-462 , Jan. 2004.

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