Topical compositions of cyclic amides as immunotherapeutic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S300000, C514S301000, C514S303000, C514S373000, C514S397000, C514S411000, C514S421000

Reexamination Certificate

active

07081464

ABSTRACT:
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.

REFERENCES:
patent: 5593990 (1997-01-01), D'Amato
patent: 5629327 (1997-05-01), D'Amato
patent: 5712291 (1998-01-01), D'Amato
patent: 5728844 (1998-03-01), Muller et al.
patent: 5728845 (1998-03-01), Muller et al.
patent: 5798368 (1998-08-01), Muller et al.
patent: 5874448 (1999-02-01), Muller et al.
patent: 5955476 (1999-09-01), Muller et al.
patent: 5968945 (1999-10-01), Muller et al.
patent: 6011050 (2000-01-01), Muller et al.
patent: 6020358 (2000-02-01), Muller et al.
patent: 6071948 (2000-06-01), D'Amato
patent: 6114355 (2000-09-01), D'Amato
patent: 6180644 (2001-01-01), Muller et al.
patent: 6214857 (2001-04-01), Muller et al.
patent: 6228879 (2001-05-01), Green et al.
patent: 6235756 (2001-05-01), D'Amato
patent: 6281230 (2001-08-01), Muller et al.
patent: 6316471 (2001-11-01), Muller et al.
patent: 6335349 (2002-01-01), Muller et al.
patent: 6380239 (2002-04-01), Muller et al.
patent: 6395754 (2002-05-01), Muller et al.
patent: 6403613 (2002-06-01), Man et al.
patent: 6420414 (2002-07-01), D'Amato
patent: 6458810 (2002-10-01), Muller et al.
patent: 6469045 (2002-10-01), D'Amato
patent: 6476052 (2002-11-01), Muller et al.
patent: 6518281 (2003-02-01), Muller et al.
patent: 6518298 (2003-02-01), Green et al.
patent: 6656964 (2003-12-01), Muller et al.
patent: 6667316 (2003-12-01), Man
patent: 6673828 (2004-01-01), Green et al.
patent: 6699899 (2004-03-01), Man et al.
patent: 2002/0173658 (2002-11-01), Muller et al.
patent: 2003/0139451 (2003-07-01), Shah et al.
patent: 2004/0147558 (2004-07-01), Treston et al.
patent: WO 94/20085 (1994-09-01), None
patent: WO 98/19649 (1998-05-01), None
patent: WO 02/064083 (2002-08-01), None
patent: WO 02/070480 (2002-09-01), None
Al-Soud and Al-Masoudi, “Synthesis and antitumor activity of some phthalimide analogues,”Pharmazie 56: 372-375 (2001).
Bauer et al., “Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent,”Biochem Pharmacol 55: 1827-1834 (1998).
Boylen et al., “Teratogenic Effects of Thalidomide and Its Metabolites on the Developing Chick Embryo,”Canadian J. of Biochem. 42: 35-42 (1964).
Buelens, “Treatment of a grade II astrocytoma with thalidomide,”Arzneimittel-Forschung 17: 646-648 (1967).
Cavala and Frith, “Phosphodiesterase Type IV Inhibitors: Structural Diversity and Therapeutic Potential In Asthma,”Current Medicinal Chemistry 2: 561-572 (1995).
Colville-Nash and Scott, “Angiogenesis and Rheumatoid Arthritis: Pathogenic and Therapeutic Implications,”Ann. Rheum. Dis. 51: 919-25 (1992).
Craig et al., “Potential anticancer agents. III. 2-phthalimidoaldehydes and derivatives,”Potential Anticancer Agents. III 10:1071-1073 (1967).
D'Amato et al., “Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma,”Semin. Oncol. 28:597-601 (2001).
D'Amato et al., “Thalidomide is an Inhibitor of Angiogenesis,”Proc. Natl. Acad. Sci. 91:4082-4085 (1994).
De and Pal, “Hansch analysis for some antineoplastic glutarimides,”J. Indian Chem. Soc. LIII: 825-826 (1976).
De and Pal, “Possible antineoplastic agents I,”J. Pharm. Sci. 64: 262-266 (1975).
De and Pal, “Possible antineoplastic agents II,”J. Pharm. Sci. 66: 232-235 (1977).
De and Ghose., “Possible antineoplastic agents: III. Synthesis of 6-alkyl-2-[4′-methoxphthalimido] and 6-alkyl-3-[3′-4′-dimethoxyphenyl] glutarimides,”J. Indian Chem. Soc. LIII: 1122-1125 (1976).
De and Ghose, “Possible antineoplastic agents: part IV—synthesis & antineoplastic potency of N-substituted α-(4,5-dimethoxyphthalimido)glutarimides & β-(4-bromophenyl)glutarimides,”Indian Jour. Chem. 16B: 510-512 (1978).
De and Pal., “Quantitative structure-activity relationship (QSAR) and rational drug design for some antineoplastic thalidomide and glutarimide derivatives,”J. Indian Chem. Soc. LIII: 1049-1052 (1976).
DiPaolo, “In vitro test systems for cancer chemotherapy, II, correlation of in vitro inhibition of dehydrogenase and growth with in vivo inhibition of Ehrlich ascites tumor,”P.S.E.B.M. 140: 384-387 (1963).
Fabro et al., “Teratogenic Activity of Thalidomide and Related Compounds,”Life Sciences 3: 987-92 (1964).
Folkman and Shing, “Angiogenesis,”J. Biol. Chem. 267: 10931-4 (1992).
Gelato et al., “Inhibition of prolactin release by a thalidomide-related compound,”P.S.E.B.M. 114: 167-168 (1972).
Gershbein, “The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas,”Cancer Lett. 60: 129-133 (1991).
Grabstald and Golbey, “Clinical experiences with thalidomide in patients with cancer,”Clinical Pharmacology and Therapeutics 6: 298-302 (1965).
Jönsson, “Chemical Structure and Teratogenic Properties,”Acta Pharma. Suecica 9: 521-542 (1972).
Koch, “The Arene Oxide Hypothesis of Thalidomide Action: Consideration s on the Molecular Mechanism of Action of the ‘Classical’ Teratogen,”Sci. Pharm. 49: 67-99 (1981).
Koch, “The Arene Oxide Hypothesis of Thalidomide Action: Consideration s on the Molecular Mechanism of Action of the ‘Classical’Teratogen,”Sci. Pharm. 49: 67-99 (1981) (English-language abstract).
Koch, “Thalidomide and Cogeners as Anti-inflammatory Agents,”Progress in Medicinal Chemistry 22: 166-242 (1985).
Lentzsch et al., “S-3-amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice,”Cancer Research62:2300-2305 (2002).
Lombardo, L.J., “Phospodiesterase-IV Inhibitors: Novel Therapeutics for the Treatment of Inflammatory Diseases,”Current Pharmaceutical Design I:255-269 (1995).
Lowe, J.A. and Cheng, J.B., “The PDE IV Family of Calcium-independent Phosphodiesterase Enzymes,”Drugs of the Future 17: 799-807 (1992).
Luzzio et al., “Synthesis and antiangiogenic activity of 2-deoxygenated analogs and 6′-deoxygenated metabolic analogs of thalidomide,”Abstracts of Papers-American Chemical Society 223: Abstract No. 185 (2002).
Menard et al., “Quelques Metabolites Possibles de la Thalidomide,”Canadian J. Chem. 41: 1722-5 (1963).
Miyachi et al., “Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity,”J. Med. Chem. 40: 2858-2865 (1997).
Mückter, “Thalidomide and tumor,”Antimicrobial Agents and Chemotherapy: 531-538 (1965).
Olson et al., “Thalidomide (N-phthaloylglutamimide) in the treatment of advanced cancer,”Clinical Pharmacology and Therapeutics 6: 292-297 (1965).
Palfreyman, “Phosphodiesterase Type IV Inhibitors As Inti-inflammatory Agents,”Drugs of the Future 20: 793-804 (1995).
Suaer et al., “Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals,”Am. J. Pathol. 156: 151-158 (2000).
Schumacher et al., “The Metabolism of Thalidomide: The Fate of Thalidomide and Some of its Hydrolysis Products in Various Species,”Brit. J. Pharmacol. 25: 338-351 (1965).
Schweigerer and Fotsis, “Angiogenesis and Angiogenesis Inhibitors in Pediatric Diseases,”Eur. J. Pediatr. 151: 472-476 (1992).
Sekut and Connolly, “Pathophysiology and Regulation of TNF-α in Inflammation,”DN&P 9: 261-269 (1996).
Shah et al., “Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis,”J. Med. Chem. 42: 3014-3017 (1999).
Shibata et al., “N-alkylphthalimides: structural requirement of thalidomidal action on 12-0-tetrad

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