Method for effecting computer implemented decision-support...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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C435S006120, C707S793000

Reexamination Certificate

active

07010431

ABSTRACT:
A method is described for effecting computer-implemented decision-support in the selection of a drug therapy of patients having a viral disease. A rules database is provided and patient data is entered including genotype data on the viral genome of the viral disease. The rules database comprises a number of associated rules for each available drug for treatment of the viral disease. Each rule indicates the suitability of the drug for treatment of a specific viral genotype. The patient data is entered into the rules database, the database providing an output of drugs suitable for therapy. The drugs suitable for therapy are displayed in a ranking in accordance with their suitability indication, for selection.

REFERENCES:
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Lathrop et al., “Knowledge-based Avoidance of Drug-Resistant HIV Mutants”,American Association of Artificial Intelligence, 1998, pp. 1071-1078.
Pazzani et al., “CTSHIV.: A Knowledge-Based System for the Management of HIV-infected Patients”,Proceedings: Intelligent Information Systems, IIS'97 (CAT. No. 97TB100201), 1997 pp. 7-13.
Lathrop et al., “Knowledge-based Avoidance of Drug-Resistant HIV Mutants”,American Association for Artificial Intelligence, Spring 1999, pp. 13-25.
Lathrop et al., “Combinatorial Optimization in Rapidly Mutating Drug-Resistant Viruses”,Journal of Combinatorial Optimization, 1999, pp. 301-320.

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