Polynucleotides encoding human amine transporter and methods of

Details Polynucleotides encoding human amine transporter and methods of Polynucleotides encoding human amine transporter and methods of

1995-06-06

1998-08-25

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 4352523, 43525411, 4353201, 435325, 536 235, 536 231, C12P 2100, C12N 1512, C12N 115, C12N 510

Patent

active

057982236

ABSTRACT:
A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.

REFERENCES:
Erickson et al. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proceedings of the National Academy of Sciences, USA. vol. 93, pp. 5166-5171, May 1996.
Lesch et al. H. sapiens mRNA for vesicular monoamine transporter. GenBank Accession No. X71354, Dec. 8, 1993.
Sambrook et al. Molecular Cloning: A Laboratory Manual, 2d Ed. CSHL Press, Cold Spring Harbor, NY, 1989.
Edwards. Mammalian synaptic vesicle amine transporter protein. GeneSeq Accession No. R47342, Dec. 23, 1993.
Erickson et al. Proc. Natl. Acad. Sci. USA, vol. 89, pp. 10993-10997 (Nov. 1992).
Peter et al. Genomics, vol. 18, No. 3, pp. 720-723 (Dec. 1993).
Krejci et al. FEBS Letters, vol. 335 No. 1, pp. 27-32 (Nov. 1993).
Surratt et al. FEBS Letters, vol. 318 No. 3, pp. 325-330 (Mar. 1993).
Liu et al. Cell, vol. 70, pp. 539-551 (Aug. 21, 1992).

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