Human megakaryocyte-associated tyrosine kinase...

Details Human megakaryocyte-associated tyrosine kinase... Human megakaryocyte-associated tyrosine kinase...

2006-04-04

2006-04-04

Monshipouri, Maryam (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S320100, C435S006120, C435S194000, C536S023200

Reexamination Certificate

active

07022510

ABSTRACT:
The invention relates to the nucleic acid of a novel human MATK-related variant (MATKV) and the polypeptides encoded thereby. The invention also provides a process for producing the polypeptide encoded by MATKV. The invention further provides the uses of the nuclei acid of MATKV and the polypeptide encoded thereby in diagnosing the disease associated with the deficiency of human MATK gene, in particular lung cancers, preferably small cell lung cancers.

REFERENCES:
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Sekido, Y., et al. “Preferential Expression of c-kitProtooncogene Transcripts in Small Cell Lung Cancer”Cancer Research, vol. 51, p. 2416-2419, (1991).
Wang, L., et al. “C-CAM1, a Candidate Tumor Suppressor Gene, Is Abnormally Expressed in Primary Lung Cancers”Clinical Cancer Research, vol. 6, p. 2988-2993, (2000).
Avraham, S., et al., “Structural and Functional Studies of the Intracellular Tyrosine Kinase MATK Gene and Its Translated Product”J. of Biological Chemistry, vol. 270, No. 4, p. 1833-1842, (1995).
Yamaguchi, N., et al. “Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for . . . dynamics”J. of Cell Science, vol. 114, p. 1631-1641, (2001).
Jhun, B.H., et al. “The MATK Tyrosine Kinase Interacts in a Specific and SH2-dependent Manner with c-Kit”J. of Biological Chemistry, vol. 270, p. 16, p. 9661-9666, (1995).
Price, D.J., et al. “Direct Association of Csk Homologous Kinase (CHK) with the Diphosphorylated Site Tyr568/570of . . . Megakaryocytes”J. of Biological Chemistry, vol. 272, No. 9, p. 5915-5920, (1997).

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