Thieno[2,3-c]iosquinolines for use as inhibitors of PARP

Details Thieno[2,3-c]iosquinolines for use as inhibitors of PARP Thieno[2,3-c]iosquinolines for use as inhibitors of PARP

2006-01-24

2006-01-24

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S080000, C546S084000, C546S089000, C546S070000, C546S062000, C514S285000, C514S292000

Reexamination Certificate

active

06989388

ABSTRACT:
The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula:wherein the constituent variables are as defined herein. The invention further provides methods for the use of the compounds disclosed herein.

REFERENCES:
patent: 4113731 (1978-09-01), Winters et al.
patent: 4263304 (1981-04-01), Ishizumi et al.
patent: WO 99/11645 (1999-11-01), None
patent: WO 99/59975 (1999-11-01), None
Compound having RN 74796-97-7.
S. Kano et al., “A facile synthesis of 4-phenylcarbostyrils and 4-phenylisocarbostyril involving photocyclization of . . . ”, (1979), Heterocycles, 12(4), pp. 489-492.

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