Assay for humoral immunity to macromolecules

Details Assay for humoral immunity to macromolecules Assay for humoral immunity to macromolecules

1995-05-25

1998-08-25

Duffy, Patricia

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 71, 435 792, 435 795, 436524, 436525, 436527, 436528, 436531, 436 72, G01N 3353

Patent

active

057982201

ABSTRACT:
A method for detecting immunogenic responses to native macromolecules. The native macromolecule is bound to a biomaterial or pharmacologic support surface and used in an immunoassay to screen biological fluids for antibodies to the macromolecule in its bound state. The method is used to screen for immune responses to implanted biomaterials and pharmacologically administered agents where native macromolecules which have interacted with the implant are conformationally altered and elicit an immune response.

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Kossovsky, N. and Papasian, N.: "Clinical Reviews: Mammary Implants," Jour.Appl.Biomaterials, vol. 3 (1992) pp. 1-4.

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