Antagonists of interleukin-15

Details Antagonists of interleukin-15 Antagonists of interleukin-15

2006-03-07

2006-03-07

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S185100, C424S193100, C435S068100, C514S002600, C530S350000, C530S351000, C530S354000, C530S362000, C530S380000

Reexamination Certificate

active

07008624

ABSTRACT:
Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.

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